The progression of alcoholic liver disease (ALD) is closely associated with the composition of fatty acids.However, the effects of specific ratios of saturated fatty acids (SFA), unsaturated fatty acids (UFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA) in oil on ALD remain unclear.This study investigated the composition and proportions of various fatty acids in sea buckthorn fruit oil (FO, rich in MUFA), seed oil (SO, rich in PUFA), and the mixed oil (MO) obtained by mixing the two in a volume ratio of 6∶4.Mice were administered oils at 0.6 g/kg body weight for 6 weeks.Results demonstrated that MO exhibited a more balanced fatty acid ratio (UFA/SFA≈3, PUFA/MUFA≈1, n-6/n-3≈2) compared to FO and SO.MO intervention significantly ameliorated liver pathology and the liver index (0.038) decreased by 17.4% compared to the model group (0.046), approaching that of the control group (0.039).Liver malondialdehyde (MDA) levels (1.16 nmol/g) decreased by 26.6% and tumor necrosis factor-α (TNF-α) levels (92.51 pg/mL) decreased by 27.7% compared to the model group (1.58 nmol/g and 127.93 pg/mL, respectively).The overall protective effect of MO surpassed that of either FO or SO alone.Gut microbiota analysis revealed that ALD mice displayed a significant increase in Erysipelotrichaceae abundance, which was reversed by MO but not effectively altered by FO.This study confirmed that the balanced fatty acid composition in sea buckthorn oil provided enhanced hepatoprotection against ALD, potentially mediated through gut microbiota modulation.
GUO Jianfeng
,
QIN Xuwei
,
ZHAO Purun
,
LI Bowen
,
HUO Nairui
,
WANG Fang
. Fatty acid ratios in sea buckthorn oil:Protection against alcoholic liver disease and gut microbiota regulation[J]. Food and Fermentation Industries, 2025
, 51(24)
: 269
-275
.
DOI: 10.13995/j.cnki.11-1802/ts.043812
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