To investigate the effects of citrus polyphenol (CP) extracts on alcoholic liver injury (ALI), CP were extracted from citrus, and an ALI mice model was established through continuous astringent administration of 56°Red Star Erguotou liquor for 21 days.ALI mice were analyzed from body weight, liver index, serum index, liver biochemical index, and pathological change in the liver.Results showed that compared with the control group, liver index were significantly reduced in the CP medium and high dose groups (P<0.05), levels of triglyceride, total cholesterol, aspartate aminotransferase, and alanine aminotransferase were significantly reduced in the CP high dose group (P<0.01).Pathologic results revealed that CP reduced alcohol-induced liver injury.Moreover, in the high-dose CP group, the activities of superoxide dismutase, catalase, and glutathione peroxidase were remarkably increased (P<0.01), while the levels of IL-6, IL-β, and TNF-α were significantly reduced (P<0.01).In conclusion, CP could effectively alleviate ALI by reducing the liver index, hepatic lipid accumulation, transaminase levels, and inflammatory cytokines, while enhancing antioxidant capacity.Therefore, CP is a promising natural agent for the protection against alcoholic liver injury and provides a theoretical basis for the development of novel hepatic protective products.
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