Research progress on bioactive components of spent coffee grounds for food industry applications

  • TANG Huihua ,
  • ZHAO Haoju ,
  • NI Jie ,
  • LI Hong ,
  • HU Yongjin
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  • 1(College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China)
    2(Institute of Agro-Products Processing, Yunnan Academy of Agricultural Sciences, Kunming 650223, China)
    3(Eryuan County Inspection and Testing Institute, Eryuan 671200, China)

Received date: 2025-07-18

  Revised date: 2025-10-01

  Online published: 2026-06-03

Abstract

The surge in global coffee consumption has resulted in an annual production of its primary by-product, Spent Coffee Grounds (SCG), exceeding 6 million tons.Conventional disposal methods like landfilling or incineration not only occupy land but also generate potent greenhouse gas methane and leach harmful substances, representing significant resource wastage.SCG is rich in valuable bioactive components, including dietary fiber (about 45.3%, primarily galactomannans and cellulose), proteins (8.5%-13.6%), lipids (18%-20%, containing phytosterols), polyphenols (e.g., chlorogenic acid, caffeic acid), and alkaloids (caffeine, trigonelline).These constituents confer antioxidant, anti-inflammatory, prebiotic, and functional enhancement properties.This review systematically analyzes the chemical characteristics and structure-activity relationships of SCG’s core components (carbohydrates, nitrogenous compounds, lipids, phenolics, alkaloids).It focuses on elucidating their high-value utilization pathways within the food industry, including applications as antioxidants in meat products, fiber-fortifying matrices in baked goods, flavor precursors in fermented beverages, functional additives in dairy products, and cultivation substrates for edible fungi.The study provides a theoretical foundation and technical reference for the resource utilization of SCG, aiming to promote the green circular development of by-products in the food industry.

Cite this article

TANG Huihua , ZHAO Haoju , NI Jie , LI Hong , HU Yongjin . Research progress on bioactive components of spent coffee grounds for food industry applications[J]. Food and Fermentation Industries, 2026 , 52(9) : 421 -430 . DOI: 10.13995/j.cnki.11-1802/ts.043957

References

[1] MITRAKA G C, KONTOGIANNOPOULOS K N, BATSIOULA M, et al.Spent coffee grounds’ valorization towards the recovery of caffeine and chlorogenic acid:A response surface methodology approach [J].Sustainability, 2021, 13(16):8818.
[2] BEVILACQUA E, CRUZAT V, SINGH I, et al.The potential of spent coffee grounds in functional food development[J].Nutrients, 2023, 15(4):994.
[3] CROSSLEY O P, THORPE R B, PEUS D, et al.Phosphorus recovery from process waste water made by the hydrothermal carbonisation of spent coffee grounds[J].Bioresource Technology, 2020, 301:122664.
[4] SABERIAN M, LI J, DONNOLI A, et al.Recycling of spent coffee grounds in construction materials:A review[J].Journal of Cleaner Production, 2021, 289:125837.
[5] DOS SANTOS É M, DE MACEDO L M, TUNDISI L L, et al.Coffee by-products in topical formulations:A review[J].Trends in Food Science & Technology, 2021, 111:280-291.
[6] 张晓霞. 绿咖啡豆中绿原酸的提取纯化及其提取物抗氧化活性的研究[D].南宁:广西大学, 2014.
ZHANG X X.Separation of chlorogenic acid from green coffee beans and the extract antioxidant activity in vitro[D].Nanning:Guangxi University, 2014.
[7] ROJAS-GONZÁLEZ A, FIGUEROA-HERNÁNDEZ C Y, GONZÁLEZ-RIOS O, et al.Coffee chlorogenic acids incorporation for bioactivity enhancement of foods:A review [J].Molecules, 2022, 27(11):3400.
[8] DATTATRAYA SARATALE G, BHOSALE R, SHOBANA S, et al.A review on valorization of spent coffee grounds (SCG) towards biopolymers and biocatalysts production [J].Bioresource Technology, 2020, 314:123800.
[9] HEJNA A.Potential applications of by-products from the coffee industry in polymer technology-Current state and perspectives[J].Waste Management, 2021, 121:296-330.
[10] OLIVEIRA G, PASSOS C P, FERREIRA P, et al.Coffee by-products and their suitability for developing active food packaging materials[J].Foods, 2021, 10(3):683.
[11] SISTI L, CELLI A, TOTARO G, et al.Monomers, materials and energy from coffee by-products:A review[J].Sustainability, 2021, 13(12):6921.
[12] BATTISTA F, ZULIANI L, RIZZIOLI F, et al.Biodiesel, biogas and fermentable sugars production from Spent coffee Grounds:A cascade biorefinery approach[J].Bioresource Technology, 2021, 342:125952.
[13] ARAUJO M N, DOS SANTOS K C, DO CARMO DINIZ N, et al.A biorefinery approach for spent coffee grounds valorization using pressurized fluid extraction to produce oil and bioproducts:A systematic review[J].Bioresource Technology Reports, 2022, 18:101013.
[14] ATABANI A E, ALI I, NAQVI S R, et al.A state-of-the-art review on spent coffee ground (SCG) pyrolysis for future biorefinery[J].Chemosphere, 2022, 286:131730.
[15] ZABANIOTOU A, KAMATEROU P.Food waste valorization advocating Circular Bioeconomy-A critical review of potentialities and perspectives of spent coffee grounds biorefinery[J].Journal of Cleaner Production, 2019, 211:1553-1566.
[16] ZHAO N, LIU Z Y, YU T, et al.Spent coffee grounds:Present and future of environmentally friendly applications on industries-a review[J].Trends in Food Science & Technology, 2024, 143:104312.
[17] BATISTA M J P A, ÁVILA A F, FRANCA A S, et al.Polysaccharide-rich fraction of spent coffee grounds as promising biomaterial for films fabrication[J].Carbohydrate Polymers, 2020, 233:115851.
[18] PÉREZ-BURILLO S, PASTORIZA S, FERNÁNDEZ-ARTEAGA A, et al.Spent coffee grounds extract, rich in mannooligosaccharides, promotes a healthier gut microbial community in a dose-dependent manner[J].Journal of Agricultural and Food Chemistry, 2019, 67(9):2500-2509.
[19] GU J, PEI W H, TANG S, et al.Procuring biologically active galactomannans from spent coffee ground (SCG) by autohydrolysis and enzymatic hydrolysis[J].International Journal of Biological Macromolecules, 2020, 149:572-580.
[20] RIBEIRO E, DE SOUZA ROCHA T, PRUDENCIO S H.Potential of green and roasted coffee beans and spent coffee grounds to provide bioactive peptides[J].Food Chemistry, 2021, 348:129061.
[21] SIMES J, NUNES F M, DOMINGUES M R, et al.Extractability and structure of spent coffee ground polysaccharides by roasting pre-treatments[J].Carbohydrate Polymers, 2013, 97(1):81-89.
[22] MOREIRA A S P, NUNES F M, DOMINGUES M R, et al.Coffee melanoidins:Structures, mechanisms of formation and potential health impacts[J].Food & Function, 2012, 3(9):903-915.
[23] 刘婧. 红糖模拟体系储藏过程类黑素理化与功能特性变化及多酚调控影响研究[D].南宁:广西大学, 2024.
LIU J.Research on changes in the physicochemical and functional properties of melanoidins and the effect of polyphenol-regulation in no-centrifugal sugar simulation system during storage[D].Nanning:Guangxi University, 2024.
[24] LÓPEZ-BARRERA D M, VÁZQUEZ-SÁNCHEZ K, LOARCA-PIÑA M G F, et al.Spent coffee grounds, an innovative source of colonic fermentable compounds, inhibit inflammatory mediators in vitro[J].Food Chemistry, 2016, 212:282-290.
[25] SHAIKH-IBRAHIM A, CURCI N, DE LISE F, et al.Carbohydrate conversion in spent coffee grounds:Pretreatment strategies and novel enzymatic cocktail to produce value-added saccharides and prebiotic mannooligosaccharides[J].Biotechnology for Biofuels and Bioproducts, 2025, 18(1):2.
[26] ZHENG Y T, WANG P Y, ZHAO G H, et al.Integrated green process for efficient mannose and mannooligosaccharides production from spent coffee grounds[J].Food Bioscience, 2024, 61:104876.
[27] RATHNAKUMAR K, OSORIO-ARIAS J C, KRISHNAN P, et al.Fractionation of spent coffee ground with tertiary amine extraction[J].Separation and Purification Technology, 2021, 274:119111.
[28] RIBEIRO G M, MARTINS P L, OLIVEIRA A C, et al.The role of mild alkaline pretreatment in the biorefinery upgrade of spent coffee grounds[J].Energies, 2023, 16(9):3907.
[29] GETACHEW A T, CHO Y J, CHUN B S.Effect of pretreatments on isolation of bioactive polysaccharides from spent coffee grounds using subcritical water[J].International Journal of Biological Macromolecules, 2018, 109:711-719.
[30] FLAMEN I.Coffee, cocoa, and tea[J].Food Reviews International, 1989, 5(3):317-414.
[31] CRUZ R, CARDOSO M M, FERNANDES L, et al.Espresso coffee residues:A valuable source of unextracted compounds[J].Journal of Agricultural and Food Chemistry, 2012, 60(32):7777-7784.
[32] MUSSATTO S I, CARNEIRO L M, SILVA J P A, et al.A study on chemical constituents and sugars extraction from spent coffee grounds[J].Carbohydrate Polymers, 2011, 83(2):368-374.
[33] KIM J, PARK Y, SHIN J, et al.Sustainable protein extraction from spent coffee grounds using response surface methodology[J].Biomass Conversion and Biorefinery, 2025, 15(12):18835-18845.
[34] VALDÉS A, CASTRO-PUYANA M, MARINA M L.Isolation of proteins from spent coffee grounds.Polyphenol removal and peptide identification in the protein hydrolysates by RP-HPLC-ESI-Q-TOF[J].Food Research International, 2020, 137:109368.
[35] VEITÍA-DE-ARMAS L, REYNEL-ÁVILA H E, BONILLA-PETRICIOLET A, et al.Green solvent-based lipid extraction from guava seeds and spent coffee grounds to produce biodiesel:Biomass valorization and esterification/transesterification route[J].Industrial Crops and Products, 2024, 214:118535.
[36] NZEKOUE F K, KHAMITOVA G, ANGELONI S, et al.Spent coffee grounds:A potential commercial source of phytosterols[J].Food Chemistry, 2020, 325:126836.
[37] CAMPOS-VEGA R, LOARCA-PIÑA G, VERGARA-CASTAÑEDA H A, et al.Spent coffee grounds:A review on current research and future prospects[J].Trends in Food Science & Technology, 2015, 45(1):24-36.
[38] IRIONDO-DEHOND A, CORNEJO F S, FERNANDEZ-GOMEZ B, et al.Bioaccesibility, metabolism, and excretion of lipids composing spent coffee grounds[J].Nutrients, 2019, 11(6):1411.
[39] SOLOMAKOU N, LOUKRI A, TSAFRAKIDOU P, et al.Recovery of phenolic compounds from spent coffee grounds through optimized extraction processes[J].Sustainable Chemistry and Pharmacy, 2022, 25:100592.
[40] MARTÍNEZ-INDA B, JIMÉNEZ-MORENO N, ESPARZA I, et al.Coffee and cocoa by-products as valuable sources of bioactive compounds:The influence of ethanol on extraction[J].Antioxidants, 2025, 14(1):42.
[41] RAMALAKSHMI K, RAO L J M, TAKANO-ISHIKAWA Y, et al.Bioactivities of low-grade green coffee and spent coffee in different in vitro model systems[J].Food Chemistry, 2009, 115(1):79-85.
[42] CASTALDO L, LOMBARDI S, GASPARI A, et al.In vitro bioaccessibility and antioxidant activity of polyphenolic compounds from spent coffee grounds-enriched cookies[J].Foods, 2021, 10(8):1837.
[43] DIAS É C P P, MACEDO G A, CAMARGO G A, et al.Effects of extraction processes on recovery, the phenolic profile, and antiglycation activity from green coffee residues (Coffea arabica and Coffea canephora Pierre)[J].ACS Sustainable Chemistry & Engineering, 2024, 12(36):13464-13474.
[44] BADR A N, EL-ATTAR M M, ALI H S, et al.Spent coffee grounds valorization as bioactive phenolic source acquired antifungal, anti-mycotoxigenic, and anti-cytotoxic activities[J].Toxins, 2022, 14(2):109.
[45] OZUNA C, MULÍK S, VALDEZ-RODRÍGUEZ B, et al.The effect of organic farming on total phenols, total flavonoids, brown compounds and antioxidant activity of spent coffee grounds from Mexico[J].Biological Agriculture & Horticulture, 2020, 36(2):107-118.
[46] VAMANU E, GATEA F, PELINESCU D R, et al.Bioavailability and bioactivities of polyphenols eco extracts from coffee grounds after in vitro digestion[J].Foods, 2020, 9(9):1281.
[47] ZENGIN G, SINAN K I, MAHOMOODALLY M F, et al.Chemical composition, antioxidant and enzyme inhibitory properties of different extracts obtained from spent coffee ground and coffee silverskin[J].Foods, 2020, 9(6):713.
[48] VÁZQUEZ-SÁNCHEZ K, MARTINEZ-SAEZ N, REBOLLO-HERNANZ M, et al.In vitro health promoting properties of antioxidant dietary fiber extracted from spent coffee (Coffee Arabica L.) grounds[J].Food Chemistry, 2018, 261:253-259.
[49] BOPPANA S H, PETERSON M, DU A L, et al.Caffeine:What is its role in pain medicine [J].Cureus, 2022, 14(6):e25603.
[50] SANTANATOGLIA A, ALESSANDRONI L, MANNOZZI C, et al.Valorization of spent coffee ground and coffee silverskin as a source of nutrients and bioactive compounds[J].Future Postharvest and Food, 2024, 1(1):61-81.
[51] FRANCA A S.Coffee:Decaffeination[M].Encyclopedia of Food and Health.Amsterdam:Elsevier, 2016:232-236.
[52] HASSAN S R, AL-YAQOOBI A M.Extraction of caffeine from spent coffee ground by solid-liquid extraction[J].Baghdad Science Journal, 2024, 21(6):2017.
[53] BOUHZAM I, CANTERO R, BALCELLS M et al.Environmental and yield comparison of quick extraction methods for caffeine and chlorogenic acid from spent coffee grounds[J].Foods, 2023, 12(4):779.
[54] KONSTANTINIDIS N, FRANKE H, SCHWARZ S, et al.Risk assessment of trigonelline in coffee and coffee by-products[J].Molecules, 2023, 28(8):3460.
[55] BEVILACQUA E, ROSE’MEYER R, SINGH I, et al.Bioactive compounds of spent coffee grounds and their potential use as functional food[J].Proceedings of the Nutrition Society, 2024, 83(OCE1):E57.
[56] HUNG Y, VERBEKE W, DE KOK T M.Stakeholder and consumer reactions towards innovative processed meat products:Insights from a qualitative study about nitrite reduction and phytochemical addition[J].Food Control, 2016, 60:690-698.
[57] CHONGSRIMSIRISAKHOL O, PIRAK T.Total polyphenol content and antioxidant properties of cold brew coffee extracts as affected by ultrasound treatment and their application in low fat pork sausage[J].International Journal of Food Properties, 2022, 25(1):813-826.
[58] KIM J H, AHN D U, EUN J B, et al.Antioxidant effect of extracts from the coffee residue in raw and cooked meat[J].Antioxidants, 2016, 5(3):21.
[59] SAMPAIO A, DRAGONE G, VILANOVA M, et al.Production, chemical characterization, and sensory profile of a novel spirit elaborated from spent coffee ground[J].LWT-Food Science and Technology, 2013, 54(2):557-563.
[60] MASINO F, MONTEVECCHI G, CALVINI R, et al.Sensory evaluation and mixture design assessment of coffee-flavored liquor obtained from spent coffee grounds[J].Food Quality and Preference, 2022, 96:104427.
[61] MACHADO E, MUSSATTO S, TEIXEIRA J, et al.Increasing the sustainability of the coffee agro-industry:Spent coffee grounds as a source of new beverages[J].Beverages, 2018, 4(4):105.
[62] LIU Y J, LU Y Y, LIU S Q.The potential of spent coffee grounds hydrolysates fermented with Torulaspora delbrueckii and Pichia kluyveri for developing an alcoholic beverage:The yeasts growth and chemical compounds modulation by yeast extracts[J].Current Research in Food Science, 2021, 4:489-498.
[63] LIU Y J, LU Y Y, LIU S Q.Untargeted LC-QTOF-MS/MS-based metabolomics of spent coffee grounds alcoholic beverages fermented with Lachancea thermotolerans and Lactiplantibacillus plantarum[J].Food Research International, 2023, 167:112733.
[64] MARTINEZ-SAEZ N, GARCÍA A T, PÉREZ I D, et al.Use of spent coffee grounds as food ingredient in bakery products[J].Food Chemistry, 2017, 216:114-122.
[65] SHARMA A, RAY A, SINGHAL R S.A biorefinery approach towards valorization of spent coffee ground:Extraction of the oil by supercritical carbon dioxide and utilizing the defatted spent in formulating functional cookies[J].Future Foods, 2021, 4:100090.
[66] HUSSEIN A, ALI H, BAREH G, et al.Influence of spent coffee ground as fiber source on chemical, rheological and sensory properties of sponge cake[J].Pakistan Journal of Biological Sciences, 2019, 22(6):273-282.
[67] AZUAN A A, MOHD ZIN Z, HASMADI M, et al.Physicochemical, antioxidant and sensory characteristics of cookies supplemented with different levels of spent coffee ground extract[J].Food Research, 2020, 4(4):1181-1190.
[68] MEERASRI J, SOTHORNVIT R.Novel development of coffee oil extracted from spent coffee grounds as a butter substitute in bakery products[J].Journal of Food Processing and Preservation, 2022, 46(7):e16687.
[69] OSORIO-ARIAS J, PÉREZ-MARTÍNEZ A, VEGA-CASTRO O, et al.Rheological, texture, structural, and functional properties of Greek-style yogurt fortified with cheese whey-spent coffee ground powder[J].LWT, 2020, 129:109523.
[70] OSORIO-ARIAS J, DELGADO-ARIAS S, DUARTE-CORREA Y, et al.New powder material obtained from spent coffee ground and whey protein;Thermal and morphological analysis[J].Materials Chemistry and Physics, 2020, 240:122171.
[71] KLANGPETCH W.Evaluation of antioxidant, anti-pathogenic and probiotic growth stimulatory activities of spent coffee ground polyphenol extracts[J].International Food Research Journal, 2017, 24(5):2246-2252.
[72] SĘCZYK Ł, ŚWIECA M, GAWLIK-DZIKI U.Soymilk enriched with green coffee phenolics-Antioxidant and nutritional properties in the light of phenolics-food matrix interactions[J].Food Chemistry, 2017, 223:1-7.
[73] ABOU FAYSSAL S, EL SEBAALY Z, ALSANAD M A, et al.Combined effect of olive pruning residues and spent coffee grounds on Pleurotus ostreatus production, composition, and nutritional value[J].PLoS One, 2021, 16(9):e0255794.
[74] ALSANAD M A, SASSINE Y N, EL SEBAALY Z, et al.Spent coffee grounds influence on Pleurotus ostreatus production, composition, fatty acid profile, and lignocellulose biodegradation capacity[J].CyTA-Journal of Food, 2021, 19(1):11-20.
[75] NGUYEN M T, RANAMUKHAARACHCHI S L.Study on the mycelium growth and primordial formation of king oyster mushroom (Pleurotus eryngii) on cardboard and spent coffee ground[J].Research on Crops, 2019, 20(4):835-842.
[76] COELHO G O, BATISTA M J A, ÁVILA A F, et al.Development and characterization of biopolymeric films of galactomannans recovered from spent coffee grounds[J].Journal of Food Engineering, 2021, 289:110083.
[77] ORHOTOHWO O L, LUCCI P, JAISWAL A K, et al.Enhancing the functional properties of chitosan-alginate edible films using spent coffee ground extract for fresh-cut fruit preservation[J].Current Research in Food Science, 2025, 11:101124.
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