Excessive drinking is easy to cause drunkenness and organ damage.To explore the anti-inebriation effects and organ-protective effects of sea buckthorn botanical beverage, this study constructed a drunken rat model induced by high-concentration alcohol.The effects of different doses of sea buckthorn botanical beverage on drunken state and behaviors, alcohol metabolism (ethanol concentration and liver alcohol dehydrogenase activity), liver alcohol injury (serum alanine aminotransferase activity, aspartate aminotransferase activity, triglyceride level, malondialdehyde level), liver oxidative stress (malondialdehyde level, reduced glutathione level, total superoxide dismutase activity) and gastrointestinal tissue (serum D-lactic acid level, endotoxin level, gastric mucosal injury degree) were analyzed.The results were as follows, and all were compared with the model group.The mortality rate and drunkenness rate of rats in each dose group were decreased,the serum alanine aminotransferase activity, aspartate aminotransferase activity, D-lactic acid concentration, and endotoxin concentration were significantly decreased, and gastric mucosal injury was alleviated;however, liver alcohol dehydrogenase activity was not significantly increased.In the middle and high dose groups, the drunken incubation period was significantly prolonged, the drunken time was significantly shortened,the rotating rod drop time and Y-maze spontaneous alternation rate were significantly increased, and serum ethanol concentration and triglyceride level were significantly decreased.Additionally, malondialdehyde level in the high-dose group was significantly decreased.The results showed that the sea buckthorn botanical beverage can reduce the alcohol exposure in the body during excessive drinking, reduce the adverse effects on the liver, gastrointestinal tract, and brain caused by excessive alcohol intake, and exert a more comprehensive anti-inebriation effect.
DUAN She
,
QIAN Yiyun
,
SUN Mingjun
,
ZHOU Jie
,
WANG Tao
,
WANG Haihong
,
WEI Min
,
LIU Xiaojing
,
YAO Dongrui
. Study on effects of sea buckthorn botanical beverage on alcohol detoxication and organs protection in alcohol-administered rats[J]. Food and Fermentation Industries, 2026
, 52(14)
: 255
-262
.
DOI: 10.13995/j.cnki.11-1802/ts.044216
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