The Sulfated fucan(SPF) was extracted by ultrasonic extraction process from the Sargassum henslowianum,purified by ethanol,and then defatted,deproteinized to the primary fucoidan.The hyperlipidemia mice fed with purified primary fucoidan showed that: the hypolipidemia effect of the high,medium and low dose of fucoidan were all superior to the zhinbiticose.And the high dose was the best.The total cholesterol,low-density lipoprotein,triglyceride were all decreased significantly(P <0.01),and high-density lipoprotein was increased significantly(P <0.05) than the control group.Arteriosclerosic index,AI1 and AI2 was decreased significantly(P<0.01).The conclusion is that the Sulfated fucan from Sargassum henslowianum has obvious activity on lowing hyperlipidemia.