To reduce the risk of Vibrio parahaemolyticus(V.p) infections associated with Tegillarca granosas consumption,the effect of tea polyphenols(TP) to V.p in both buffering peptone water(BPW) and Tegillarca granosas was researched in this study.3-tube most probable number method(MPN method) was used to measure the population of V.p in Tegillarca granosas.The results indicated that 0.5 g/L of TP was the minimum inhibitory concentration(MIC) against V.p.Populations of V.p in Tegillarca granosas treated with 0.5 g/L of TP and stored at 0℃,5℃ and 10℃ all decreased sharply by 2.75,2.59 and 2.15 Log10 MPN/g within 60 h respectively and 99% of V.p were killed.Sensory analysis indicated that tegillarca granosas treated with 0.5 g/L of TP can be accepted by consumers.These results indicated that TP have bactericidal effects against V.p and can be applied to Tegillarca granosas to reduce contamination of V.p.