For enhancing Resveratrol content of the grape skin residues,solving the low production of Resveratrol and the problem of high production costs,in this paper,the following contents were studied:1 applying single factor with the orthogonal solid-state fermentation to deal with the grape skin residues that produced wine by fermentation;2 using ultrasound and high-performance liquid chromatography to extract and detect the Resveratrol separately.The main results were as follows:at 28 ℃,the optimization of solid-state fermentation conditions were the ratio of solid to liquid of the fermentation was 1∶2.0(m∶m),the fermentation time was 72 h,carbon(glucose)amount was 0.15 g /g.The highest Resveratrol content may reach to 1.846 mg /L and was 3.46 times more than those not-fermenting.Solid-state fermentation treatment can significantly increase Resveratrol of grape skin residue in the yield.