To optimize the process of extracting effective constituents from Folium eriobotryae by response surface methodology.The independent variables were ethanol concentration,extracting time and solvents ratio.The dependent variable was extracting rate of total flavonoids.Composite design and response surface methods were used to optimize the extracting process,a two-order polynomial equation was fitted,and model was used to predict the response in the optimal region.the optimum conditions of extraction process were:73%% ethanol,140 minutes for reflux,11.5 fold solvent and 2 times for extraction.The optimum model is highly predictive.