[1] 刘文虎.北京市将慢性肾病列入“首都十大慢病”[J].首都食品与医药,2017,24(7):44.
LIU W H.Beijing has listed chronic kidney disease among the “Top Ten Chronic Diseases in the Capital”[J].Capital Food and Medicine,2017,24(7):44.
[2] 冯哲,陈香美.中国急性肾损伤的防治策略[J].华西医学,2018,33(7):777-781.
FENG Z,CHEN X M.Prevention and treatment strategies for acute kidney injury in China[J].West China Medical Journal,2018,33(7):777-781.
[3] TAMPE B,STEINLE U,TAMPE D,et al.Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury-to-chronic kidney disease progression[J].Kidney International,2017,91(1):157-176.
[4] 冯湘沅,成莉凤,谢纯良,等.不同品种黄麻叶多糖的理化特征及抗氧化活性研究[J].天然产物研究与开发,2020,8:1 278-1 284.
FENG X Y,CHEN L F,XIE C L,et al.Study on the physicochemical characteristics and antioxidant activity of different varieties of jute leaf polysaccharides[J].Research and Development of Natural Products,2020,8:1 278-1 284.
[5] LIM W C,CHOI J W,SONG N E,et al.Polysaccharide isolated from persimmon leaves (Diospyros kaki Thunb.) suppresses TGF-β1-induced epithelial-to-mesenchymal transition in A549 cells[J].International Journal of Biological Macromolecules,2020,164:3 835-3 845.
[6] YAO W Z,VEERAPERUMAL S,QIU H M,et al.Anti-cancer effects of Porphyra haitanensis polysaccharides on human colon cancer cells via cell cycle arrest and apoptosis without causing adverse effects in vitro[J].3 Biotech,2020,10(9):386.
[7] LUO Y,PENG B,WEI W,et al.antioxidant and anti-diabetic activities of polysaccharides from guava leaves[J].Molecules,2019,24(7):1 343.
[8] CAO Y G,HAO Y,LI Z H,et al.Antiviral activity of polysaccharide extract from Laminaria japonica against respiratory syncytial virus[J].Biomedical & Pharmacotherapy,2016,84:1 705-1 710.
[9] WANG Q,MENG X,ZHU L,et al.A polysaccharide found in Paulownia fortunei flowers can enhance cellular and humoral immunity in chickens[J].International Journal of Biological Macromolecules,2019,130:213-219.
[10] 周欣,邓青芳.天然产物对化学性肝损伤的影响及作用机制研究进展[J].贵州师范大学学报(自然科学版),2018,36(5):1-11;122.
ZHOU X,DENG Q F.Research progress on the effects of natural products on chemical liver injury and its mechanism[J].Journal of Guizhou Normal University (Natural Science Edition),2018,36(5):1-11;122.
[11] 付婷婷,王国贤,陈婷婷,等.黄精多糖对糖尿病肾病大鼠肾脏的保护作用[J].中药药理与临床,2015,31(4):123-126.
FU T T,WANG G X,CHEN T T,et al.Protective effects of Polygonatum polysaccharides on the kidneys of diabetic nephropathy rats[J].Pharmacology and Clinics of Chinese Materia Medica,2015,31(4):123-126.
[12] ZHAO Q,LI J,YAN J,et al.Lycium barbarum polysaccharides ameliorates renal injury and inflammatory reaction in alloxan-induced diabetic nephropathy rabbits[J].Life Sciences,2016,157:82-90.
[13] 周东月,王春璐,任艳平,等.黄连多糖通过抑制氧化应激和炎症反应减轻糖尿病大鼠肾损伤的实验研究[J].中国比较医学杂志,2019,29(3):37-42;10.
ZHOU DY,WANG CL,REN YP,et al.Experimental study of Rhizoma coptidis polysaccharides in reducing kidney injury in diabetic rats by inhibiting oxidative stress and inflammation[J].Chinese Journal of Comparative Medicine,2019,29(3):37-42;10.
[14] 王苑蓉,叶大杰.马齿笕多糖对高脂饲料联合链脲佐菌素诱导的糖尿病肾病大鼠的作用及机制[J].广西医科大学学报,2018,35(8):1 050-1 053.
WANG YR,YE DJ.Effects and mechanisms of horse tooth polysaccharides on high-fat diet combined with streptozotocin-induced diabetic nephropathy in rats[J].Journal of Guangxi Medical University,2018,35(8):1 050-1 053.
[15] LIU Z Z,WENG H B,ZHANG L J,et al.Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling[J].Chinese Journal of Natural Medicines,2019,17(9):641-649.
[16] 蔡忠华,钟保恒,宋美桂,等.牛心柿叶多糖对糖尿病小鼠肾脏损伤的保护作用[J].中国实验方剂学杂志,2013,19(1):261-264.
CAI ZH,ZHONG B H,SONG MG,et al.Protective effect of Niuxin persimmon leaf polysaccharides on kidney injury in diabetic mice[J].Chinese Journal of Experimental Formulas,2013,19(1):261-264.
[17] 毛明锋,雷文晖,周丽美,等.红芪多糖对糖尿病小鼠肾脏组织α-SMA表达及肾小管间质损伤的影响研究[J].浙江医学,2019,41(5):424-427.
MAO M F,LEI W H,ZHOU L M,et al.Study on the effect of Hedysarius polysaccharides on the expression of α-SMA and renal tubular interstitial damage in diabetic mice[J].Zhejiang Medicine,2019,41(5):424-427.
[18] 郭福团,许雄伟,潘建峰,等.桑枝多糖对糖尿病肾病小鼠肾皮质氧化应激作用的影响[J].中国药理学通报,2016,32(8):1 148-1 152.
GUO F T,XU X W,PAN J F,et al.Effect of mulberry twig polysaccharide on oxidative stress in renal cortex of diabetic nephropathy mice[J].Chinese Pharmacological Bulletin,2016,32(8):1 148-1 152.
[19] CONG G,CUI L,ZANG M,et al.Attenuation of renal ischemia/reperfusion injury by a polysaccharide from the roots of Dipsacus asperoides[J].International Journal of Biological Macromolecules,2013,56:14-19.
[20] 王虹,尹显华,胡水清.黄芪多糖对大鼠缺血再灌注急性肾损伤的保护作用及机制研究[J].中国免疫学杂志,2019,35(16):1 966-1 969.
WANG H,YIN X H,HU S Q.The protective effect and mechanism of astragalus polysaccharides on acute kidney injury caused by ischemia-reperfusion in rats[J].Chinese Journal of Immunology,2019,35(16):1 966-1 969.
[21] LI Z,ZHU L,ZHANG H,et al.Protective effect of a polysaccharide from stem of Codonopsis pilosula against renal ischemia/reperfusion injury in rats[J].Carbohydrate Polymers,2012,90(4):1 739-1 743.
[22] LIU Z,LI C,ZHANG Q,et al.Effect of Renshen polysaccharides on oxidative injury in kidney IR rabbits[J].Carbohydrate Polymers,2012,90(2):773-777.
[23] 沈蓉. 蕨麻多糖对镉所致肾毒性的保护作用及其机制研究[D].兰州:兰州大学,2017.
SHEN R.The protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity and its mechanism[D].Lanzhou:Lanzhou University,2017.
[24] 蒋平. 黄精对染镉小鼠肾损伤的治疗作用研究[D].合肥:安徽农业大学,2017.
JIANG P.Study on the therapeutic effect of Polygonatum on kidney injury in mice exposed to cadmium[D].Hefei:Anhui Agricultural University,2017.
[25] WU T,SHEN M,LIU S,et al.Ameliorative effect of Cyclocarya paliurus polysaccharides against carbon tetrachloride induced oxidative stress in liver and kidney of mice[J].Food and Chemical Toxicology.2020,135:111 014.
[26] 樊小宝,吴雅岚,王晶,等.金钗石斛多糖对多柔比星肾病大鼠肾纤维化及PI3K/Akt/HIF-1α通路的影响[J].中国药师,2019,22(10):1 835-1 840.
FAN X B,WU Y L,WANG J,et al.Effects of Dendrobium nobile polysaccharides on renal fibrosis and PI3K/Akt/HIF-1α Pathway in doxorubicin nephropathy rats[J].China Pharmacist,2019,22(10):1 835-1 840.
[27] 陈浩然. 海带多糖对阿霉素诱导的肾损伤干预作用[D].合肥:合肥工业大学,2018.
CHEN H R.Intervention effect of kelp polysaccharide on adriamycin-induced renal injury[D].Hefei:Hefei University of Technology,2018.
[28] 王爱青.党参多糖对肾阴虚大鼠抗氧化活性和免疫调节影响[J].中医药临床杂志,2018,30(2):287-290.
WANG A Q.The effect of Codonopsis pilosula polysaccharide on the antioxidant activity and immune regulation in rats with kidney-yin deficiency[J].Clinical Journal of Traditional Chinese Medicine,2018,30(2):287-290.
[29] RAISH M,AHMAD A,JAN B L,et al. Momordica charantia polysaccharides mitigate the progression of STZ induced diabetic nephropathy in rats[J].International of Biological Macromolecules,2016,91:394-399.
[30] RIHAB B,NEILA J,FATEN H,et al.Anti-obesity effect and protection of liver-kidney functions by Codium fragile sulphated polysaccharide on high fat diet induced obese rats[J].International Journal of Biological Macromolecules,2017,102:119-129.
[31] 樊艳玲,夏婕妤,贾道勇,等.当归多糖对D-半乳糖致小鼠肾脏亚急性损伤的保护作用及机制[J].中国中药杂志,2015,40(21):4 229-4 233.
FAN Y L,XIA J Y,JIA D Y,et al.Protective effect and mechanism of angelica polysaccharide on D-galactose-induced renal subacute injury in mice[J].China Journal of Chinese Materia Medica,2015,40(21):4 229-4 233.
[32] BEN ABDALLAH KOLSI R,BKHAIRIA I,GARGOURI L,et al.Protective effect of Sargussum vulgare sulfated polysaccharide against molecular,biochemical and histopathological damage caused by alloxan in experimental diabetic rats[J].International Journal of Biological Macromolecules,2017,105(1):598-607.
[33] 张利英,卢志伟,许小敏,等.当归多糖对辐射大鼠肾脏氧化应激防护作用及Nrf2相关机制研究[J].中药药理与临床,2017,33(5):63-66.
ZHANG L Y,LU Z W,XU X M,et al.The protective effect of angelica polysaccharide on oxidative stress in the kidney of irradiated rats and the related mechanism of Nrf2[J].Pharmacology and Clinics of Chinese Materia Medica,2017,33(5):63-66.
[34] 方晴. 海带多糖对慢性肾功能衰竭及并发性血管钙化的干预作用[D].合肥:合肥工业大学,2016.
FANG Q.Intervention of kelp polysaccharides on chronic renal failure and concurrent vascular calcification[D].Hefei:Hefei University of Technology,2016.
[35] OGALSKA A,SUCAJTYSSZULC E,SWIERCZYNSKI J.Leptin decreases lipogenic enzyme gene expression through modification of SREBP-1c gene expression in white adipose tissue of aging rats[J].Metabolism:Clinical and Experimental,2005,54(8):1 041-1 047.
[36] 李易,叶曦.三七多糖对糖尿病肾病大鼠炎症反应及脂质代谢调节作用的实验研究[J].中国中医药科技,2018,25(1):43-47.
LI Y,YE X.Experimental study of the effects of Panax notoginseng polysaccharide on inflammatory response and lipid metabolism in diabetic nephropathy rats[J].China Journal of Traditional Chinese Medicine Science and Technology,2018,25(1):43-47.
[37] 蔡淑敏,曾振华,傅卫军,等.减阻聚合物芦荟多糖对脓毒症大鼠肾功能的保护作用[J].临床麻醉学杂志,2015,31(11):1 109-1 112.
CAI S M,ZENG Z H,FU W J,et al.Protective effect of drag-reducing polymer aloe polysaccharide on renal function in septic rats[J].The Journal of Clinical Anesthesiology,2015,31(11):1 109-1 112.
[38] WANG S,SUN Z,YANG S,et al.CTRP6 inhibits cell proliferation and ECM expression in rat mesangial cells cultured under TGF-β1[J].Biomedical & Pharmacotherapy,2018,97:280-285.
[39] CHO N,RAZIPOUR S E,MCCAIN M L.Featured Article:TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts[J].Experimental Biology and Medicine,2018,243(7):601-612.
[40] 黄倩,林佩璜,郑丹丹,等.桑枝多糖预防性给药对肾缺血再灌注损伤模型小鼠炎症反应的影响及机制研究[J].中国药房,2019,30(13):1 786-1 791.
HUANG Q,LIN P H,ZHENG D D,et al.Study on the effect and mechanism of preventive administration of mulberry twig polysaccharide on inflammatory response in mice with renal ischemia-reperfusion injury[J].China Pharmacy,2019,30(13):1 786-1 791.
[41] 王晶洁.桑枝多糖对2型糖尿病大鼠心肌及肾功能的保护作用[J].中西医结合心脑血管病杂志,2019,17(19):2 936-2 938.
WANG J J.Protective effects of mulberry twig polysaccharides on myocardial and renal function in type 2 diabetic rats[J].Journal of Integrated Traditional Chinese and Western Medicine Cardio-Cerebrovascular Disease,2019,17(19):2 936-2 938.
[42] HAN X,SONG C,FENG X,et al.Isolation and hypoglycemic effects of water extracts from mulberry leaves in Northeast China[J].Food Function,2020,11(4):3 112-3 125.
[43] 吴俊.当归多糖改善炎症性贫血和肾性贫血的作用及机制研究[D].武汉:华中科技大学,2018.
WU J.Research on the effect and mechanism of angelica polysaccharide in improving inflammatory anemia and renal anemia[D].Wuhan:Huazhong University of Science and Technology,2018.
[44] 李菁菁. 枸杞多糖对DN兔肾脏组织炎症损伤及其相关机制的影响[D].武汉:武汉大学,2014.
LI J J.Effects of Lycium barbarum polysaccharides on inflammatory injury and related mechanisms of DN rabbit kidney tissue[D].Wuhan:Wuhan University,2014.
[45] SHEN R,LIU D,HOU C,et al.Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo[J].Food Function,2017,8(10):3 636-3 646.
[46] MA Q,XU Y,TANG L,et al.Astragalus polysaccharide attenuates cisplatin-induced acute kidney injury by suppressing oxidative damage and mitochondrial dysfunction[J].BioMed Research International,2020.DOI:10.1155/2020/2851349.
[47] AKIN D,OZMEN S,YILMAZ M E.Hyaluronic acid as a new biomarker to differentiate acute kidney injury from chronic kidney disease[J].Iranian Journal of Kidney Diseases,2017,11(6):409-413.
[48] HUANG F,SUN X Y,OUYANG J M.Preparation and characterization of selenized Astragalus polysaccharide and its inhibitory effect on kidney stones[J].Materials Science & Engineering C,2020,110:110 732.
[49] HAN J,GUO D,SUN X Y,et al.Comparison of the adhesion and endocytosis of calcium oxalate dihydrate to HK-2 cells before and after repair by Astragalus polysaccharide[J].Science and Technology of Advanced Materials,2019,20(1):1 164-1 177.
[50] USHA P,CAROL P.The role of toll-like receptors in diabetic kidney disease[J].Current Opinion in Nephrology and Hypertension,2018,27(1):30-34.
[51] WANG Y,ZHONG J,ZHANG X,et al.The role of HMGB1 in the pathogenesis of type 2 diabetes[J].Journal of Diabetes Research,2016,2 543 268.
[52] 马淑芳,王庆奎,戴伟,等.当归多糖对点带石斑鱼Toll样受体22信号通路相关基因表达的影响[J].大连海洋大学学报,2017,32(1):33-37.
MA S F,WANG Q K,DAI W,et al.Effects of Angelica polysaccharides on the expression of genes related to the Toll-like receptor 22 signaling pathway in Epinephelus sphaerocephala[J].Journal of Dalian Ocean University,2017,32(1):33-37.
[53] 李承德,王煜,曲敬蓉,等.黄芪多糖对糖尿病大鼠肾脏TGF-β1/Smads信号通路的影响[J].中国药理学通报,2018,34(4):512-516.
LI C D,WANG Y,QU J R,et al.Effects of Astragalus polysaccharides on TGF-β1/Smads signaling pathway in diabetic rats[J].Chinese Pharmacological Bulletin,2018,34(4):512-516.
[54] DONG X,GAN Y,DING L,et al.Effect of jiawei fengshining on synovial cell apoptosis and TGF-β1/smad signaling pathway in rats with rheumatoid arthritis[J].Evidence-based Complementary and alternative medicine:eCAM.2019,2019:8 614 034.
[55] SEHRAWAT A,SHIOTA C,MOHAMED N,et al.SMAD7 enhances adult β-cell proliferation without significantly affecting β-cell function in mice[J].The Journal of Biological Chemistry,2020,295(15):4 858-4 869.
[56] HOU G,JIN M,YE Z,et al.Ameliorate effects of soybean soluble polysaccharide on adenine-induced chronic renal failure in mice[J].International Journal of Biological Macromolecules,2020,149:158-164.
[57] 石毅琼. 基于TGF-β1/Smads信号通路探讨当归多糖干预糖尿病肾病的作用机制[D].兰州:兰州大学,2018.
SHI Y Q.Based on the TGF-β1/Smads signaling pathway to explore the mechanism of angelica polysaccharide in intervention of diabetic nephropathy[D].Lanzhou:Lanzhou University,2018.
[58] WANG P,WANG W,SHI Q,et al.Paeoniflorin ameliorates acute necrotizing pancreatitis and pancreatitis-induced acute renal injury[J].Molecular Medicine Reports,2016,14(2):1 123-1 131.
[59] 陈伟,谢林伸.黄芪多糖抑制p38MAPK信号通路减轻缺氧复氧肾小管上皮细胞炎症反应[J].免疫学杂志,2019,35(7):593-598.
CHEN W,XIE L S.Astragalus polysaccharide inhibits p38MAPK signaling pathway and reduces the inflammatory response of hypoxia-reoxygenation renal tubular epithelial cells[J].Chinese Journal of Immunology,2019,35(7):593-598.
[60] 高子涵,李瑞芳,吕行直,等.山药多糖对糖尿病肾病小鼠肾功能和醛糖还原酶通路的影响[J].中药材,2019,42(3):643-646.
GAO Z H,LI R F,LU X Z,et al.The effect of yam polysaccharides on renal function and aldose reductase pathway in mice with diabetic nephropathy[J].Chinese Medicinal Materials,2019,42(3):643-646.
[61] HAN C,SUN T,LIU Y,et al.Protective effect of Polygonatum sibiricum polysaccharides on gentamicin-induced acute kidney injury in rats via inhibiting p38 MAPK/ATF2 pathway[J].International Journal of Biological Macromolecules,2020,151:595-601.
[62] 李新朋. 低分子量褐藻多糖硫酸酯的制备及治疗肾纤维化的研究[D].北京:中国科学院大学(中国科学院海洋研究所),2017.
LI X P.Preparation of low molecular weight fucoidan and its treatment of renal fibrosis[D].Beijing:University of Chinese Academy of Sciences (Institute of Oceanology,Chinese Academy of Sciences),2017.
[63] LI X Y,CHEN H R,ZHA X Q,et al.Prevention and possible mechanism of a purified Laminaria japonica polysaccharide on adriamycin-induced acute kidney injury in mice[J].International Journal of Biological Macromolecules,2020,148:591-600.
[64] HUANG L H,LIU H,CHEN J Y,et al.Seaweed Porphyra yezoensis polysaccharides with different molecular weights inhibit hydroxyapatite damage and osteoblast differentiation of A7R5 cells[J].Food Functions,2020,11(4):3 393-3 409.
[65] FENG Y,WENG H,LING L,et al.Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice[J].International Journal of Biological Macromolecules,2019,132:1 001-1 011.
[66] WEI W,LI Z P,BIAN Z X,et al.Astragalus polysaccharide RAP induces macrophage phenotype polarization to M1 via the Notch signaling pathway[J].Molecules,2019,24(10):2 016.
[67] WANG Y,TIAN Y,SHAO J,et al.Macrophage immunomodulatory activity of the polysaccharide isolated from Collybia radicata mushroom[J].International Journal of Biological Macromolecules,2018,108:300-306.
[68] ZHANG W,ZHANG M,CHENG A,et al.Immunomodulatory and antioxidant effects of Astragalus polysaccharide liposome in large yellow croaker (Larimichthys crocea)[J].Fish and Shellfish Immunology,2020,100:126-136.
[69] 徐伟,黄微,倪向荣.丹参多酚酸盐联合连续性肾脏替代治疗急性肾损伤患者的疗效及预后作用[J].世界中西医结合杂志,2020,15(9):1 744-1 746;1 755.
XU W,HUANG W,NI X G.Efficacy and prognosis of Salvia miltiorrhiza polyphenolate combined with continuous renal replacement therapy in patients with acute kidney injury[J].World Journal of Integrated Traditional Chinese and Western Medicine,2020,15(9):1 744-1 746;1 755.
[70] 伦立德,章友康.代谢性疾病肾损害的治疗药物进展与合理用药-肾脏疾病合理用药专家圆桌会议纪要[J].中国医院用药评价与分析,2010,10(12):1 057-1 059.
LUN L D,ZHANG Y K.Progress and rational use of drugs for the treatment of renal damage in metabolic diseases:Summary of the roundtable meeting of experts on the rational use of drugs for renal diseases[J].Evaluation and Analysis of Drug Use in China Hospital,2010,10(12):1 057-1 059.
