Introduction to Oil Processing is a core course of the National First-Class Undergraduate program in Food Science and Technology of Jiangnan University. This course aims to develop students’ professional knowledge of oil processing and focuses on improving their engineering practice and their ability to analyze and solve practical problems. However, the current teaching has problems such as teaching content emphasizes on theory but not practice; teaching methods emphasize on explanation but not inspiration; knowledge application emphasizes on imitation but not innovation; faculty focuses on research but not teaching. Based on the above problems, the direction of teaching reform of Introduction to Oil Processing is to train students’ practical ability by the integration of theory and practice in knowledge structure, to stimulate students’ learning interest by the combination of multiple teaching methods in classroom teaching, to train students’ operational and innovative ability by the integration of classroom teaching and extra-curricular extension in talent training mode, and to strengthen teachers’ construction by simultaneously improving teachers’ scientific research and teaching level. In this way, the objectives of Introduction to Oil Processing course can be better achieved, and the organic unity of knowledge transfer and competence training for students can be realized. After the teaching update, student evaluation and supervisor evaluation of this course have improved significantly, and the overall teaching quality ranking of Introduction to Oil Processing in 2020 and 2021 was ranked in the top 2% of all courses at School of Food Science and Technology, Jiangnan University. In addition, students have won numerous awards at top national subject competitions and have received many honors at school and provincial level. This demonstrates a significant increase in students’ knowledge and innovation, and provides a highly qualified and professional workforce for the sustainable development of the lipids industry.