Food and Fermentation Industries >

2023 , Vol. 49 >Issue 2: 159 - 165

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.029867

Effects of different doses of Lycium chinensis and seabuckthorn on immune function of mice

  • YANG Ni ,
  • LI Ying ,
  • ZHU Jiawen ,
  • ZHOU Xianjia ,
  • BAI Jiarui ,
  • LIU Yang ,
  • XI Zhumei
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  • 1(College of Enology, Northwest A&F University, Yangling 712100, China)
    2(Qinghai Light Industry Institute Co.Ltd., Xining 810001, China)

Received date: 2021-11-09

  Revised date: 2021-12-07

  Online published: 2023-02-15

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Abstract

To explore the effects of different doses of Lycium barbarum and seabuckthorn on the immune function of mice, mice were orally given 0.35, 0.70, and 1.05 g/kg·BW of Lycium barbarum and seabuckthorn capsule powder for 30 d, and the organs/body weight ratio was measured respectively. The indexes of mice were determined by ConA-induced spleen lymphocyte transformation test, delayed-type hypersensitivity (DTH) induced by DNFB, serum hemolysin test, carbon clearance ability test, antibody-producing cells test, NK cell activity test, and peritoneal macrophage phagocytosis of chicken red blood cells test. Results showed that compared with the negative control group, the high-dose group (1.05 g/kg·BW) could significantly enhance the ConA-induced splenic lymphocyte transformation ability, DTH reaction induced by DNFB, phagocytosis rate, phagocytosis index, carbon clearance phagocytosis index, NK cell activity and the number of antibody-producing cells, and the differences were significant (P<0.05). The middle-dose group (0.70 g/kg·BW) could significantly increase the number of antibodies in mice, and the differences were significant (P<0.05), which indicated that the product was positive for both cellular and humoral immune function, and had the effect of enhancing immunity. This study finally proved that the compatibility of Lycium barbarum and seabuckthorn could be used to develop immunity-enhancing products.

Key words： Lycium barbarum; seabuckthorn; immunity; compatibility; immune function

Cite this article

YANG Ni , LI Ying , ZHU Jiawen , ZHOU Xianjia , BAI Jiarui , LIU Yang , XI Zhumei . Effects of different doses of Lycium chinensis and seabuckthorn on immune function of mice[J]. Food and Fermentation Industries, 2023 , 49(2) : 159 -165 . DOI: 10.13995/j.cnki.11-1802/ts.029867

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