Food and Fermentation Industries >

2023 , Vol. 49 >Issue 2: 181 - 186

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.029932

Study on the in vitro antioxidant activity of proanthocyanidins from Cerasus humilis and its protective effect onliver injury in mice

  • XU Xiaoyin ,
  • TIAN Zhengfu ,
  • ZHANG Huiling
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  • 1(Ningxia Key Laboratory for Food Microbial-Applications Technology and Safety Control, Yinchuan 750021, China)
    2(School of Food and Wine, Ningxia University,Yinchuan 750021, China)

Received date: 2021-11-08

  Revised date: 2021-12-14

  Online published: 2023-02-15

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Abstract

This paper aimed to study the in vitro antioxidant activity of Cerasus humilis and the protective effect of carbon tetrachloride-induced liver injury in mice. In vitro antioxidant studies hadshownprocyanidin standard scavenging ability>procyanidin sample>ascorbic acid.Sixty male ICR mice were randomly divided into six groups including normal,model,positive control,and low-, medium-and high-dose groups.The liver injury model was induced by intraperitoneal injection of CCl4,dosing lasted five weeks, and the animals were then killed after overnight fasting of 18h.Blood samples were collected from the heart to determine the activities of alanine aminotransferase(ALT),and aspartate aminotransferase(AST) in the serum of mice.Liver tissue homogenate was prepared to measure the content of total superoxide dismutase(SOD) activity,glutathione peroxidase(GSH-Px) activity,and malondialdehyde (MDA) concentration.Compared with the model group,thehigh-dose group′s ALT and AST activities in the serum decreased significantly(P<0.01),medium-and high-dose group′s SOD and GSH-Px activities in the serum decreased significantly(P<0.01),it showedtheextraction ofproanthocyanidins from Cerasus humilis had significant protective effects against CCl4-induced liver injury in male ICR mice.

Key words： Cerasus humilis; proanthocyanidins; antioxidant; liver injury; carbon tetrachloride

Cite this article

XU Xiaoyin , TIAN Zhengfu , ZHANG Huiling . Study on the in vitro antioxidant activity of proanthocyanidins from Cerasus humilis and its protective effect onliver injury in mice[J]. Food and Fermentation Industries, 2023 , 49(2) : 181 -186 . DOI: 10.13995/j.cnki.11-1802/ts.029932

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