Food and Fermentation Industries >

2023 , Vol. 49 >Issue 4: 97 - 102

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.030551

Effect of chitooligosaccharide compound solid beverage on reducing uric acid in hyperuricemia mice

  • ZHUANG Lin ,
  • CAO Jun ,
  • LI Yuechan ,
  • WANG Jiali ,
  • CHEN Liehuan ,
  • LUO Xuegang
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  • 1(Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, School of Bioengineering, Tianjin University of Science and Technology, Tianjin 300457, China)
    2(New Youlan Health and Technology Co. Ltd., Guangzhou 510530, China)
    3(Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control, Tianjin 300457, China)

Received date: 2021-12-22

  Revised date: 2022-01-27

  Online published: 2023-03-20

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Abstract

To explore the uric acid-lowering effect of chitooligosaccharide solid beverage (ke suan ping, KSP) in hyperuricemia mice, a total of 60 Kunming mice were divided into 6 groups, including a negative control group (NC), hyperuricemia model group (M), and low-dose KSP group (LKSP), middle-dose KSP group (MKSP), high-dose KSP group (HKSP), and allopurinol group (AP). After one week of adaptive feeding, hyperuricemia mice were injected with potassium oxonate and supplemented with yeast extracts. At the same time, the fodders of mice in KSP groups were changed into the forages containing KSP in different doses. The mice in the AP group were administered with PBS buffer after injection. The test lasted 21 days. Serum of mice was collected for the detection of uric acid (UA), creatinine (CR), urine urea nitrogen (BUN), and xanthine oxidase (XOD). And the mouse liver, kidney, and small intestine were collected for HE staining and q-PCR. Results showed that KSP could reduce serum UA, CR, and BUN and the activities of XOD in hyperuricemia mice, alleviate the damage of the liver and kidney in hyperuricemia mice, and regulate the mRNA expression of GLUT9, URAT1, and ABCG2. In short, KSP could reduce UA by inhibiting the activity of XOD and promoting the excretion of UA in hyperuricemia.

Key words： chitooligosaccharides; hyperuricemia; uric acid; xanthine oxidase; liver damage; urate transporter

Cite this article

ZHUANG Lin , CAO Jun , LI Yuechan , WANG Jiali , CHEN Liehuan , LUO Xuegang . Effect of chitooligosaccharide compound solid beverage on reducing uric acid in hyperuricemia mice[J]. Food and Fermentation Industries, 2023 , 49(4) : 97 -102 . DOI: 10.13995/j.cnki.11-1802/ts.030551

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