The effects of eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA) combined with maltodextrin (MED) dietary on the gut flora, blood organic acids and visceral distribution of lipids in type Ⅱ diabetic rats were investigated. SD rat diabetes model was established by intraperitoneal administration of streptozotocin and oral administration of different doses of MED. The fasting blood glucose, visceral coefficient and lipid visceral distribution were detected. The blood and feces of the subject rats were collected for the blood organic acid detection (by HPLC), and for 16S rDNA amplicon sequencing analysis to obtain the information of intestinal flora in diabetic rat. The results showed that MED gavage, especially in middle dosage, had a certain alleviation effect on polydipsia and the augment of organ coefficient induced by diabetes mellitus but would cause lipids accumulation in solid organs. For the changes of intestinal flora induced by diabetes, middle-dose MED tended to restore the relative abundance of some dominant beneficial flora. MED could in some extent alleviate the diabetes-triggered alteration of blood organic acids as propionic acid, butanoic acid, isopentanoic acid and n-pentanoic acid. MED could alleviate the alteration of polydipsia, hyperglycemia, organ coefficient and intestinal flora caused by type Ⅱ diabetes (no statistical significance), but would induce lipids accumulation in visceral organs, Hence, it should be applied with caution.
JIANG Bianling
,
WANG Weiwei
,
ZHAO Chengyang
,
ZHANG Dongxin
,
ZHAO Xudong
,
CHEN Jun
,
PENG Lei
,
CHEN Qiong
,
FENG Fan
. Effect of eicosapentaenoic acid and docosahexaenoic acid combined with maltodextrin dietary on gut microflora, blood organic acids, and lipids distribution in diabetic rats[J]. Food and Fermentation Industries, 2023
, 49(4)
: 202
-208
.
DOI: 10.13995/j.cnki.11-1802/ts.033561
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