Delivery system based on emulsion-templated method: Enhancing the stability and bioavailability of bioactive compounds

  • JIANG Ling ,
  • WANG Qiming ,
  • RAO Zhenan ,
  • CHEN Yuanyuan ,
  • LEI Xiaojuan ,
  • MING Jian
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  • 1(College of Food Science, Southwest University, Chongqing 400715, China)
    2(Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400715, China)

Received date: 2022-04-13

  Revised date: 2022-05-12

  Online published: 2023-04-14

Abstract

Functional foods and dietary supplements rich in bioactive substances can prevent and alleviate many chronic diseases. However, bioactive substances have poor stability, they are easily decomposed and inactivated by light, heat, and oxygen during production, processing, and storage, and are easily converted and inactivated by enzymes, gastric acid, and bile salts after entering the gastrointestinal tract of the human body, showing low bioavailability. The design of the delivery system is considered as a good strategy to improve the stability and bioavailability of bioactive substances. There are many methods to construct the delivery system, and the emulsion-templated method has attracted extensive attention due to its simple preparation, outstanding stability, and ability to bring specific functions to the system. Therefore, this paper introduced the basic principles of the emulsion-templated method, the preparation of various food delivery systems based on the emulsion-templated method, and their application effects in the delivery of various bioactive compounds. Finally, this paper summarized the advantages of the emulsion-templated method and proposed the research directions of the delivery system based on the emulsion-templated method.

Cite this article

JIANG Ling , WANG Qiming , RAO Zhenan , CHEN Yuanyuan , LEI Xiaojuan , MING Jian . Delivery system based on emulsion-templated method: Enhancing the stability and bioavailability of bioactive compounds[J]. Food and Fermentation Industries, 2023 , 49(6) : 292 -299 . DOI: 10.13995/j.cnki.11-1802/ts.031970

References

[1] 吴航. 食品组学在生物活性化合物营养功能特性研究中的应用[J].中国食品, 2021(17):150-151.
WU H.Application of food genomics in the study of nutritional functional characteristics of bioactive compounds[J].China Food, 2021(17):150-151.
[2] 邢晨, 王俐娟, 王晓琴.可食用植物不同形态酚类化合物研究进展[J].食品科学, 2020, 41(5):266-275.
XING C, WANG L J, WANG X Q.Recent studies on free and bound phenolic compounds in edible plants:A review[J].Food Science, 2020, 41(5):266-275.
[3] BOONLAO N, RUKTANONCHAI U R, ANAL A K.Enhancing bioaccessibility and bioavailability of carotenoids using emulsion-based delivery systems[J].Colloids and Surfaces. B,Biointerfaces, 2022, 209(Pt2):112211.
[4] BURGAIN J, GAIANI C, LINDER M, et al.Encapsulation of probiotic living cells:From laboratory scale to industrial applications[J].Journal of Food Engineering, 2011, 104(4):467-483.
[5] KANDEMIR K, TOMAS M, MCCLEMENTS D J, et al.Recent advances on the improvement of quercetin bioavailability[J].Trends in Food Science & Technology, 2022, 119:192-200.
[6] YIN Z Y, ZHENG T, HO C T, et al.Improving the stability and bioavailability of tea polyphenols by encapsulations:A review[J].Food Science and Human Wellness, 2022, 11(3):537-556.
[7] ZHANG L M, ZHENG J Q, WANG Y, et al.Fabrication of rhamnogalacturonan-I enriched pectin-based emulsion gels for protection and sustained release of curcumin[J].Food Hydrocolloids, 2022, 128:107592.
[8] ALDEMIR DIKICI B, CLAEYSSENS F.Basic principles of emulsion templating and its use as an emerging manufacturing method of tissue engineering scaffolds[J].Frontiers in Bioengineering and Biotechnology, 2020, 8:875.
[9] 崔梦楠, 鹿瑶, 高彦祥, 等.食品乳液凝胶的制备及其应用研究进展[J].食品科学, 2019, 40(3):323-329.
CUI M N, LU Y, GAO Y X, et al.A review on the preparation and application of food emulsion gels[J].Food Science, 2019, 40(3):323-329.
[10] 饶哲楠, 陈媛媛, 王启明, 等.食品水凝胶-多酚递送体系构建及其提高多酚生物利用度研究进展[J].食品与发酵工业, 2022, 48(7):304-311.
RAO Z N, CHEN Y Y, WANG Q M, et al.Construction of food hydrogel-polyphenol delivery system and their enhancement of polyphenol bioavailability:A review[J].Food and Fermentation Industries, 2022, 48(7):304-311.
[11] SELVASEKARAN P, CHIDAMBARAM R.Food-grade aerogels obtained from polysaccharides, proteins, and seed mucilages:Role as a carrier matrix of functional food ingredients[J].Trends in Food Science & Technology, 2021, 112:455-470.
[12] ZHAO W J, WEI Z H, XUE C H.Recent advances on food-grade oleogels:Fabrication, application and research trends[J].Critical Reviews in Food Science and Nutrition, 2022, 62(27):7 659-7 676.
[13] LI Y Z, LIU J M, HE X F, et al.Preparation of cinnamon oil-loaded antibacterial composite microcapsules by in situ polymerization of pickering emulsion templates[J].Macromolecular Materials and Engineering, 2020, 305(3):1900851.
[14] SUNG M R, XIAO H, DECKER E A, et al.Fabrication, characterization and properties of filled hydrogel particles formed by the emulsion-template method[J].Journal of Food Engineering, 2015, 155:16-21.
[15] 沈娟莉, 付时雨.纤维素基水凝胶的研究进展[J].化工进展, 2022, 41(6):3 022-3 037.
SHEN L J, FU S Y.Research progress of cellulose-based hydrogels[J].Chemical Industry and Engineering Progress, 2022, 41(6):3 022-3 037.
[16] 太敏瑞, 蔡泓滢, 李瑞, 等.多糖-蛋白质复合水凝胶研究进展[J].食品与发酵工业, 2022, 48(3):291-297.
TAI M R, CAI H Y, LI R, et al.Research progress of polysaccharide-protein composite hydrogels[J].Food and Fermentation Industries, 2022, 48(3):291-297.
[17] MCCLEMENTS D J.Recent progress in hydrogel delivery systems for improving nutraceutical bioavailability[J].Food Hydrocolloids, 2017, 68:238-245.
[18] 丁玲, 唐艺华, 张丽芬, 等.花生蛋白-果胶复合乳液凝胶的流变学特性和微观结构[J].食品科学, 2022, 43(16):46-52.
DING L, TANG Y H, ZHANG L F, et al.Rheological properties and microstructure of peanut protein-pectin composite emulsion gel[J].Food Science, 2022, 43(16):46-52.
[19] MIAO J Y, XU N, CHENG C, et al.Fabrication of polysaccharide-based high internal phase emulsion gels:Enhancement of curcumin stability and bioaccessibility[J].Food Hydrocolloids, 2021, 117:106679.
[20] 穆硕, 鹿瑶, 高彦祥, 等.果胶和热处理对蛋白质乳液凝胶结构特性和复合维生素稳定性的影响[J].食品科学, 2018, 39(18):29-34.
MU S, LU Y, GAO Y X, et al.Effect of pectin and preheating on the structure and stability of mixed vitamins in protein emulsion gels[J].Food Science, 2018, 39(18):29-34.
[21] LU Y, MAO L K, ZHENG H X, et al.Characterization of β-carotene loaded emulsion gels containing denatured and native whey protein[J].Food Hydrocolloids, 2020, 102:105600.
[22] UBEYITOGULLARI A, CIFTCI O N.Fabrication of bioaerogels from camelina seed mucilage for food applications[J].Food Hydrocolloids, 2020, 102:105597.
[23] VERONOVSKI A, TKALEC G, KNEZ Ž, et al.Characterisation of biodegradable pectin aerogels and their potential use as drug carriers[J].Carbohydrate Polymers, 2014, 113:272-278.
[24] KLEEMANN C, SCHUSTER R, ROSENECKER E, et al.In-vitro-digestion and swelling kinetics of whey protein, egg white protein and sodium caseinate aerogels[J].Food Hydrocolloids, 2020, 101:105534.
[25] WU W N, WU Y Y, LIN Y, et al.Facile fabrication of multifunctional citrus pectin aerogel fortified with cellulose nanofiber as controlled packaging of edible fungi[J].Food Chemistry, 2022, 374:131763.
[26] ESPERT M, SALVADOR A, SANZ T.Cellulose ether oleogels obtained by emulsion-templated approach without additional thickeners[J].Food Hydrocolloids, 2020, 109:106085.
[27] GAO Z M, YANG X Q, WU N N, et al.Protein-based Pickering emulsion and oil gel prepared by complexes of zein colloidal particles and stearate[J].Journal of Agricultural and Food Chemistry, 2014, 62(12):2 672-2 678.
[28] PAN H B, XU X L, QIAN Z Q, et al.Xanthan gum-assisted fabrication of stable emulsion-based oleogel structured with gelatin and proanthocyanidins[J].Food Hydrocolloids, 2021, 115:106596.
[29] KIM J C, LEE H Y, KIM M H, et al.Preparation and characterization of chitosan/gelatin microcapsules containing triclosan[J].Colloids and Surfaces. B,Biointerfaces, 2006, 52(1):52-56.
[30] 马明月,姜宏宇,张华.紫苏油微胶囊的性质与体外模拟消化研究[J].中国粮油学报, 2022, 37(5):102-108.
MA M Y, JIANG H Y, ZHANG H.The properties of perilla oil microcapsules and simulated digestion in vitro[J].Journal of the Chinese Cereals and Oils Association, 2022, 37(5):102-108.
[31] LI D X, OH Y K, LIM S J, et al.Novel gelatin microcapsule with bioavailability enhancement of ibuprofen using spray-drying technique[J].International Journal of Pharmaceutics, 2008, 355(1-2):277-284.
[32] 付聪, 董鸿春, 刘玥婷, 等.番茄红素的微胶囊化、稳定性及生物利用率的研究进展[J].食品工业科技, 2022, 43(11):391-397.
FU C, DONG H C, LIU Y T, et al.Research progress on microencapsulation, stability and bioavailability of lycopene[J].Science and Technology of Food Industry, 2022, 43(11):391-397.
[33] 徐娜. 基于Pickering乳液模板法的姜精油微胶囊的性能表征及其肠道菌群调节作用[D].南京:南京财经大学, 2021.
XU N.Pickering emulsion templating methodology-based ginger essential oil microcapsules and their performance and effect on regulation of intestinal microbiota[D].Nanjing:Nanjing University of Finance and Economics, 2021.
[34] MANACH C, WILLIAMSON G, MORAND C, et al.Bioavailability and bioefficacy of polyphenols in humans.I.Review of 97 bioavailability studies[J].The American Journal of Clinical Nutrition, 2005, 81(1):230S-242S.
[35] MUÑOZ-GONZÁLEZ I, RUIZ-CAPILLAS C, SALVADOR M, et al.Emulsion gels as delivery systems for phenolic compounds:Nutritional, technological and structural properties[J].Food Chemistry, 2021, 339:128049.
[36] BELŠČAK-CVITANOVIĆ A, BUŠIĆ A, BARIŠIĆ L, et al.Emulsion templated microencapsulation of dandelion (Taraxacum officinale L.) polyphenols and β-carotene by ionotropic gelation of alginate and pectin[J].Food Hydrocolloids, 2016, 57:139-152.
[37] DU X Q, HU M, LIU G N, et al.Development and evaluation of delivery systems for quercetin:A comparative study between coarse emulsion, nano-emulsion, high internal phase emulsion, and emulsion gel[J].Journal of Food Engineering, 2022, 314:110784.
[38] HASKELL M J.The challenge to reach nutritional adequacy for vitamin A:β-carotene bioavailability and conversion:Evidence in humans[J].The American Journal of Clinical Nutrition, 2012, 96(5):1 193S-1 203S.
[39] GUO J, JIANG J G, GU X L, et al.Encapsulation of β-carotene in calcium alginate hydrogels templated by oil-in-water-in-oil (O/W/O) double emulsions[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects, 2021, 608:125548.
[40] 黄玉. 蛋白-多酚胶体复合物制备油凝胶及其性质研究[D].广州:暨南大学, 2018.
HUANG Y.Preparation and characterization of oleogel based on protein-polyphenol colloidal complex[D].Guangzhou:Jinan University, 2018.
[41] ZHANG Z, CHEN W C, ZHOU X, et al.Astaxanthin-loaded emulsion gels stabilized by Maillard reaction products of whey protein and flaxseed gum:Physicochemical characterization and in vitro digestibility[J].Food Research International(Ottawa,Ont.), 2021, 144:110321.
[42] LIU F G, LIANG X P, YAN J, et al.Tailoring the properties of double-crosslinked emulsion gels using structural design principles:Physical characteristics, stability, and delivery of lycopene[J].Biomaterials, 2022, 280:121265.
[43] 汤友军, 鲁晓翔.植物精油稳定性的改善及其在食品中应用研究进展[J].食品工业科技, 2020, 41(7):353-357.
TANG Y J, LU X X.Research progress on stability improvement of plant essential oil and its application in food[J].Science and Technology of Food Industry, 2020, 41(7):353-357.
[44] 谢晓婷, 刘康珂, 邓爱华, 等.迷迭香提取物在功能食品领域研究进展[J].广东化工, 2020, 47(4):107-108;106.
XIE X T, LIU K K, DENG A H, et al.Research progress of rosemary extract in functional food[J].Guangdong Chemical Industry, 2020, 47(4):107-108;106.
[45] WANG J G, LI Y Z, GAO Y F, et al.Cinnamon oil-loaded composite emulsion hydrogels with antibacterial activity prepared using concentrated emulsion templates[J].Industrial Crops and Products, 2018, 112:281-289.
[46] 张珊珊, 冯武, 熊芸, 等.乳液模板-层层自组装法制备百里香精油微胶囊[J].食品工业, 2018, 39(8):87-92.
ZHANG S S, FENG W, XIONG Y, et al.Preparation of thyme essential oil microcapsules from emulsion templates by layer-by-layer self-assembly method[J].The Food Industry, 2018, 39(8):87-92.
[47] ZHANG S, CHEN J, YIN X Q, et al.Microencapsulation of tea tree oil by spray-drying with methyl cellulose as the emulsifier and wall material together with chitosan/alginate[J].Journal of Applied Polymer Science, 2017, 134(13):44662.
[48] DE VOS P, FAAS M M, SPASOJEVIC M, et al.Encapsulation for preservation of functionality and targeted delivery of bioactive food components[J].International Dairy Journal, 2010, 20(4):292-302.
[49] KAILASAPATHY K.Survival of free and encapsulated probiotic bacteria and their effect on the sensory properties of yoghurt[J].LWT-Food Science and Technology, 2006, 39(10):1 221-1 227.
[50] 邓伶俐, 刘松奇, 易顺, 等.海藻酸钠/壳聚糖气凝胶对酸面团来源植物乳杆菌的包埋分析[J].中国食品学报, 2021, 21(8):291-297.
DENG L L, LIU S Q, YI S, et al.Analysis of the encapsulation effect of Lactobacillus plantarum from sourdough by sodium alginate/chitosan aerogel[J].Journal of Chinese Institute of Food Science and Technology, 2021, 21(8):291-297.
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