Food and Fermentation Industries >

2023 , Vol. 49 >Issue 9: 49 - 56

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.032342

Effects of sea buckthorn fermented tea on blood lipid and gut microbiota in high-fat diet rats

  • KOU Jing ,
  • SHI Linna ,
  • ZHANG Yimin ,
  • HUAN Cheng ,
  • MA Tianyi
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  • (School of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China)

Received date: 2022-05-18

  Revised date: 2022-08-11

  Online published: 2023-06-05

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Abstract

This study aimed to explore the influence of sea buckthorn fermented tea on blood lipid and gut microflora in hyperlipidemia rats. Healthy male SD rats were randomly divided into four groups: normal control group (NC, n=8), hyperlipidemia model group (HF, n=8), sea buckthorn group (HFS, n=8) and fermented tea group (HFF, n=8). The experiment was conducted for eight weeks. Feces were collected for high-throughput sequencing of gut microbiota in the last week. After executed, the serum and liver were collected for blood lipid detection and pathological analysis. The results showed that sea buckthorn fermented tea could significantly reduce the levels of cholesterol, triglyceride and low density lipoprotein in hyperlipidemia rats, increase the levels of high density lipoprotein, and alleviate the liver damage caused by high fat diet. Sequencing analysis demonstrated that sea buckthorn fermented tea could significantly improve the abundance and uniformity of the intestinal flora in rat, increase the relative abundance of beneficial bacteria , inhibit the pathogenic bacteria , and restored gut microbiota disorder caused by high-fat diet. In conclusion, sea buckthorn fermented tea could be a potentially effective strategy to alleviate blood lipid level, liver damage and the gut microbiota disturbance in hyperlipidemia rats.

Key words： sea buckthorn fermented tea; high-fat diet; gut microflora; microbiota analysis; high-throughput sequencing

Cite this article

KOU Jing , SHI Linna , ZHANG Yimin , HUAN Cheng , MA Tianyi . Effects of sea buckthorn fermented tea on blood lipid and gut microbiota in high-fat diet rats[J]. Food and Fermentation Industries, 2023 , 49(9) : 49 -56 . DOI: 10.13995/j.cnki.11-1802/ts.032342

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