Research progress on the application of microbial agents to alleviate hyperoxaluria

  • XU Mingyue ,
  • TAN Zhuoming ,
  • WANG Guangqiang ,
  • XIONG Zhiqiang ,
  • SONG Xin ,
  • YANG Yijin ,
  • ZHANG Hui ,
  • AI Lianzhong ,
  • XIA Yongjun
Expand
  • (Shanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200000, China)

Received date: 2022-11-24

  Revised date: 2023-01-04

  Online published: 2023-06-30

Abstract

Excessive accumulation of oxalate in the human body will lead to hyperoxaluria, which is easy to cause kidney stones. At present, there are no specific drugs can alleviate hyperoxaluria, but there are oxalate-degrading microorganisms in the intestine that can degrade oxalate in the body through various pathways. The gut-kidney axis pathway indicated that the gut microbial diversity and the abundance of oxalate-degrading bacteria are significantly higher in normal human than those in patients with hyperoxaluria, so increasing the oxalate-degrading microorganisms in the gut of patients is a potential way to alleviate the disease. Strains of Oxalobacter formigenes, Lactobacillus, Streptococcus and Bifidobacterium with oxalate degrading function have been widely used in vivo. This article summarizes the microbial agent and mechanisms of alleviation for the treatment of hyperoxaluria, including functional flora in feces, probiotics, genetically engineered bacteria, in order to provide theoretical reference for the research on the treatment of hyperoxaluria with probiotics.

Cite this article

XU Mingyue , TAN Zhuoming , WANG Guangqiang , XIONG Zhiqiang , SONG Xin , YANG Yijin , ZHANG Hui , AI Lianzhong , XIA Yongjun . Research progress on the application of microbial agents to alleviate hyperoxaluria[J]. Food and Fermentation Industries, 2023 , 49(11) : 288 -297 . DOI: 10.13995/j.cnki.11-1802/ts.034414

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