[1] STERN R, JEDRZEJAS M J.Hyaluronidases:Their genomics, structures, and mechanisms of action[J].Chemical Reviews,2006, 106 (3):818-839.
[2] BAKKE M, KAMEI J I, OBATA A.Identification, characterization, and molecular cloning of a novel hyaluronidase, a member of glycosyl hydrolase family 16, from Penicillium spp[J].FEBS Letters, 2011, 585(1):115-120.
[3] JEDRZEJAS M J, STERN R.Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis[J].Proteins, 2005, 61(2):227-238.
[4] SUN X Q, WANG Z, BI Y L, et al.Genetic and functional characterization of the hyaluronate lyase HylB and the beta-N-acetylglucosaminidase HylZ in Streptococcus zooepidemicus[J].Current Microbiology, 2015, 70(1):35-42.
[5] RIGDEN D J, JEDRZEJAS M J.Genome-based identification of a carbohydrate binding module in Streptococcus pneumoniae hyaluronate lyase[J].Proteins, 2003, 52(2):203-211.
[6] RIGDEN D J, GALPERIN M Y, JEDRZEJAS M J.Analysis of structure and function of putative surface-exposed proteins encoded in the Streptococcus pneumoniae genome:A bioinformatics-based approach to vaccine and drug design[J].Critical Reviews in Biochemistry and Molecular Biology, 2003, 38(2):143-168.
[7] MISHRA P, AKHTAR M S, BHAKUNI V.Unusual structural features of the bacteriophage-associated hyaluronate lyase (hylp2)[J].Journal of Biological Chemistry, 2006, 281(11):7143-7150.
[8] RIGDEN D J, JEDRZEJAS M J.Structures of Streptococcus pneumoniae hyaluronate lyase in complex with chondroitin and chondroitin sulfate disaccharides insights into specificity and mechanism of action[J].Journal of Biological Chemistry, 2003, 278(50):50596-50606.
[9] LEPPERDINGER G, STROBL B, KREIL G.HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity[J].Journal of Biological Chemistry, 1998, 273(35):22466-22470.
[10] REESE K L, ARAVINDAN R G, GRIFFITHS G S, et al.Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1:Evidence for a role for hyaluronidase 3 in mouse and human sperm[J].Molecular Reproduction and Development, 2010, 77(9):759-772.
[11] NARITA T, TOBISAWA Y, BOBKOV A, et al.TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity[J] Journal of Biological Chemistry, 2023, 299(9):105120.
[12] YAMAMOTO H, TOBISAWA Y, INUBUSHI T, et al.A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase[J].Journal of Biological Chemistry,2017, 292(18):7304-7313.
[13] NEHMÉ R, NASREDDINE R, ORLIC L, et al.Kinetic theory of hyaluronan cleavage by bovine testicular hyaluronidase in standard and crowded environments[J].Biochimica et Biophysica Acta (BBA-General Subjects), 2021,1865(3):129837.
[14] KRUPKOVA O, GREUTERT H, BOOS N, et al.Expression and activity of hyaluronidases HYAL-1, HYAL-2 and HYAL-3 in the human intervertebral disc[J].European Spine Journal, 2020, 29(3):605-615.
[15] WEBER G C, BUHREN B A, SCHRUMPF H, et al.Clinical applications of hyaluronidase[J].Advances in Experimental Medicine and Biology, 2019, 1148:255-277.
[16] 任璐. 重组人透明质酸酶在 CHO 表达系统中的表达及纯化研究[D].长春:吉林大学, 2019.
REN L.Expression and purification of rhPH-20 in CHO expression system[D].Changchun:Jilin University, 2019.
[17] MARKOVIĆ-HOUSLEY Z, MIGLIERINI G, SOLDATOVA L, et al.Crystal structure of hyaluronidase, a major allergen of bee venom[J].Structure, 2000, 8(10):1025-1035.
[18] XU X, WANG X S, XI X T, et al.Purification and partial characterization of hyaluronidase from five pace snake (Agkistrodon acutus) venom[J].Toxicon, 1982, 20(6):973-981.
[19] BORDON K C F, PERINO M G, GIGLIO J R, et al.Isolation, enzymatic characterization and antiedematogenic activity of the first reported rattlesnake hyaluronidase from Crotalus durissus terrificus venom[J].Biochimie, 2012, 94(12):2740-2748.
[20] VIVAS-RUIZ D E, GONZALEZ-KOZLOVA E E, DELGADILLO J, et al.Biochemical and molecular characterization of the hyaluronidase from Bothrops atrox Peruvian snake venom[J].Biochimie, 2019, 162:33-45.
[21] AMORIM F G, BOLDRINI-FRANÇA J, DE CASTRO FIGUEIREDO BORDON K, et al.Heterologous expression of rTsHyal-1:The first recombinant hyaluronidase of scorpion venom produced in Pichia pastoris system[J].Applied Microbiology and Biotechnology, 2018, 102(7):3145-3158.
[22] FENG L, GAO R, GOPALAKRISHNAKONE P.Isolation and characterization of a hyaluronidase from the venom of Chinese red scorpion Buthus martensi[J].Comparative Biochemistry and Physiology Part C:Toxicology & Pharmacology, 2008,148(3):250-257.
[23] MOREY S S, KIRAN K M, GADAG J R.Purification and properties of hyaluronidase from Palamneus gravimanus (Indian black scorpion) venom[J].Toxicon, 2006, 47(2):188-195.
[24] REITINGER S, BOROVIAK T, LASCHOBER G T, et al.High-yield recombinant expression of the extremophile enzyme, bee hyaluronidase in Pichia pastoris[J].Protein Expression and Purification, 2008, 57(2):226-233.
[25] RUNGSA P, JANPAN P, SAENGKUN Y, et al.Heterologous expression and mutagenesis of recombinant Vespa affinis hyaluronidase protein (rVesA2)[J].The Journal of Venomous Animals and Toxins Including Tropical Diseases, 2019, 25:e20190030.
[26] TU A T, HENDON R R.Characterization of lizard venom hyaluronidase and evidence for its action as a spreading factor[J].Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1983, 76(2):377-383.
[27] DA C B GOUVEIA A I, DA SILVEIRA R B, NADER H B, et al.Identification and partial characterisation of hyaluronidases in Lonomia obliqua venom[J].Toxicon, 2005, 45(4):403-410.
[28] RASH L D, HODGSON W C.Pharmacology and biochemistry of spider venoms[J].Toxicon, 2002, 40(3):225-254.
[29] HOTEZ P, CAPPELLO M, HAWDON J, et al.Hyaluronidases of the gastrointestinal invasive nematodes Ancylostoma caninum and Anisakis simplex:Possible functions in the pathogenesis of human zoonoses[J].The Journal of Infectious Diseases, 1994, 170(4):918-926.
[30] NAGARAJU S, DEVARAJA S, KEMPARAJU K.Purification and properties of hyaluronidase from Hippasa partita (funnel web spider) venom gland extract[J].Toxicon, 2007, 50(3):383-393.
[31] MADOKORO M, UEDA A, KIRIAKE A, et al.Properties and cDNA cloning of a hyaluronidase from the stonefish Synanceia verrucosa venom[J].Toxicon, 2011, 58(4):285-292.
[32] HUANG H, LIANG Q X, WANG Y, et al.High-level constitutive expression of leech hyaluronidase with combined strategies in recombinant Pichia pastoris[J].Applied Microbiology and Biotechnology, 2020, 104(4):1621-1632.
[33] LEVY-ADAM F, MIAO H Q, HEINRIKSON R L, et al.Heterodimer formation is essential for heparanase enzymatic activity[J].Biochemical and Biophysical Research Communications, 2003, 308(4):885-891.
[34] JIN P, KANG Z, ZHANG N, et al.High-yield novel leech hyaluronidase to expedite the preparation of specific hyaluronan oligomers[J].Scientific Reports, 2014, 4:4471.
[35] HYNES W L, WALTON S L.Hyaluronidases of gram-positive bacteria[J].FEMS Microbiology Letters, 2000, 183(2):201-207.
[36] JEDRZEJAS M J.Unveiling molecular mechanisms of pneumococcal surface protein A interactions with antibodies and lactoferrin[J].Clinica Chimica Acta; International Journal of Clinical Chemistry, 2006, 367(1-2):1-10.
[37] STING R, SCHAUFUSS P, BLOBEL H.Isolation and characterization of hyaluronidases from Streptococcus dysgalactiae, S.zooepidemicus and S.equi[J].Zentralblatt Für Bakteriologie, 1990, 272(3):276-282.
[38] 郭学平. 芽孢杆菌 Bacillus sp.A50 透明质酸酶的研究[D].济南:山东大学, 2014.
GUO X P.Study on the hyaluronidase from Bacillus sp.A50[D].Jinan:Shandong University, 2014.
[39] SMIRNOU D, KRCˇMÁRˇ M, KULHÁNEK J, et al.Characterization of hyaluronan-degrading enzymes from yeasts[J].Applied Biochemistry and Biotechnology, 2015, 177(3):700-712.
[40] SUN J H, HAN X, SONG G R, et al.Cloning, expression, and characterization of a new glycosaminoglycan lyase from Microbacterium sp.H14[J].Marine Drugs, 2019, 17(12):681.
[41] ZHU C L, ZHANG J L, LI L Y, et al.Purification and characterization of hyaluronate lyase from Arthrobacter globiformis A152[J].Applied Biochemistry and Biotechnology, 2017, 182(1):216-228.
[42] JEDRZEJAS M J, MEWBOURNE R B, CHANTALAT L, et al.Expression and purification of Streptococcus pneumoniae hyaluronate lyase from Escherichia coli[J].Protein Expression and Purification, 1998, 13(1):83-89.
[43] JEDRZEJAS M J, CHANTALAT L.Structural studies of Streptococcus agalactiae hyaluronate lyase[J].Acta Crystallographica Section D-Biological crystallography, 2000, 56(Pt 4):460-463.
[44] EL-SAFORY N S, LEE G C, LEE C K.Characterization of hyaluronate lyase from Streptococcus pyogenes bacteriophage H4489A[J].Carbohydrate Polymers, 2011, 84(3):1182-1191.
[45] INGHAM E, HOLLAND K T, GOWLAND G, et al.Purification and partial characterization of hyaluronate lyase (EC 4.2.2.1) from Propionibacterium acnes[J].Journal of General Microbiology, 1979, 115(2):411-418.
[46] TAO L, SONG F, XU N Y, et al.New insights into the action of bacterial chondroitinase AC I and hyaluronidase on hyaluronic acid[J].Carbohydrate Polymers, 2017,158:85-92.
[47] GIRISH K S, KEMPARAJU K.The magic glue hyaluronan and its eraser hyaluronidase:A biological overview[J].Life Sciences, 2007, 80(21):1921-1943.
[48] MESSINA L, GAVIRA J A, PERNAGALLO S, et al.Identification and characterization of a bacterial hyaluronidase and its production in recombinant form[J].FEBS Letters, 2016, 590(14):2180-2189.
[49] HAN W J, WANG W S, ZHAO M, et al.A novel eliminase from a marine bacterium that degrades hyaluronan and chondroitin sulfate[J].Journal of Biological Chemistry, 2014, 289(40):27886-27898.
[50] HYNES W L, DIXON A R, WALTON S L, et al.The extracellular hyaluronidase gene (hylA) of Streptococcus pyogenes[J].FEMS Microbiology Letters, 2000,184(1):109-112.
[51] HU W S, PENG T T, HUANG Y, et al.Hyaluronidase-powered microneedles for significantly enhanced transdermal delivery efficiency[J].Journal of Controlled Release, 2023,353:380-390.
[52] KNUDSON W.Tumor-associated hyaluronan. Providing an extracellular matrix that facilitates invasion[J].American Journal of Pathology, 1996,148(6):1721-1726.
[53] WANG S B, LI Y X, XU C N, et al.An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy[J].Journal for Immunotherapy of Cancer, 2024,12(3):e008431.
[54] MCBRIDE W H, BARD J B.Hyaluronidase-sensitive halos around adherent cells.Their role in blocking lymphocyte-mediated cytolysis[J].The Journal of Experimental Medicine, 1979,149(2):507-515.
[55] NEVES E R, ANAND A, MUELLER J, et al.Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties[J].bioRxiv, 2024:2024.01.05.574065.
[56] FROST G I, MOHAPATRA G, WONG T M, et al.HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA[J].Oncogene, 2000,19(7):870-877.
[57] RIECKS J, PARNIGONI A, GYÖRFFY B, et al.The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer[J].Journal of Cancer Research and Clinical Oncology, 2022,148(12):3399-3419.
[58] STERN R.Hyaluronan metabolism:A major paradox in cancer biology[J].Pathologie Biologie, 2005, 53(7):372-382.
[59] SINGH S, MAURYA A K, MEENA A, et al.Narirutin.A flavonoid found in Citrus fruits modulates cell cycle phases and inhibits the proliferation of hormone-refractory prostate cancer cells by targeting hyaluronidase[J].Food and Chemical Toxicology, 2023,174:113638.
[60] CARTON F, MALATESTA M.Nanotechnological research for regenerative medicine:The role of hyaluronic acid[J].International Journal of Molecular Sciences, 2024, 25(7):3975.
[61] 李强. 不饱和透明质酸二糖的制备和活性研究[D].济南:山东大学, 2013.
LI Q.Study on the preparation and biological activities of 4,5-unsaturated hyaluronate disaccharide[D].Jinan:Shandong University, 2013.
[62] TOLG C, TELMER P, TURLEY E.Specific sizes of hyaluronan oligosaccharides stimulate fibroblast migration and excisional wound repair[J].PLoS One, 2014, 9(2):e88479.
[63] JORDAN A R, LOKESHWAR S D, LOPEZ L E, et al.Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer[J].Oncotarget, 2017, 8(15):24262-24274.
[64] XU H P, ITO T, TAWADA A, et al.Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72[J].Journal of Biological Chemistry, 2002, 277(19):17308-17314.
[65] OHNO S, IM H J, KNUDSON C B, et al.Hyaluronan oligosaccharide-induced activation of transcription factors in bovine articular chondrocytes[J].Arthritis and Rheumatism, 2005, 52(3):800-809.
[66] 吕梦娴. 透明质酸四糖和六糖的制备及生物活性研究[D].无锡:江南大学, 2016.
LYU M X.Study on the preparation and biological activities of hyaluronan tetrasaccharide and hexasaccharide[D].Wuxi:Jiangnan University, 2016.
[67] TAKAHASHI Y, LI L L, KAMIRYO M, et al.Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner[J].Journal of Biological Chemistry,2005,280(25):24195-24204.
[68] 张莲. 硫酸软骨素寡糖的制备及其体外抗氧化活性研究[D].无锡:江南大学, 2012.
ZHANG L.Preparation and antioxidant activity in vitro of chondroitin sulfate oligosaccharides[D].Wuxi:Jiangnan University, 2012.
[69] WANG Y, HU L T, HUANG H, et al.Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineered Corynebacterium glutamicum[J].Nature Communications, 2020,11(1):3120.
[70] CHOWPONGPANG S, SHIN H S, KIM E K.Cloning and characterization of the bovine testicular PH-20 hyaluronidase core domain[J].Biotechnology Letters, 2004, 26(15):1247-1252.
[71] LIAO L Z, HUANG H, WANG Y, et al. Yeast surface display of leech hyaluronidase for the industrial production of hyaluronic acid oligosaccharides[J].Engineering Microbiology,2023,3(4):100086.
[72] YANG P F, LEE C K.Purification of recombinant hyaluronan lyase of Streptococcus pyogenes bacteriophage H4489A expressed in Escherichia coli and its application for the specific determination of hyaluronan concentration[J].Carbohydrate Polymers, 2006, 65(2):159-164.
[73] SCHWAIGHOFER A, ABLASSER S, LUX L et al.Production of active recombinant hyaluronidase inclusion bodies from Apis mellifera in E.coli BL21(DE3) and characterization by FT-IR Spectroscopy[J].International Journal of Molecular Sciences, 2020, 21(11):3881.
[74] GUO X P, LIU F, ZHU X Q, et al.Expression of a novel hyaluronidase from Streptococcus zooepidemicus in Escherichia coli and its application for the preparation of HA oligosaccharides[J].Carbohydrate Polymers, 2009, 77(2):254-260.
[75] 陈怡斐, 李茜茜, 荣绍丰, 等.重组兽疫链球菌透明质酸酶在大肠杆菌中的表达及其酶活力[J].中国医药工业杂志, 2015, 46(11):1173-1177.
CHEN Y F, LI Q Q, RONG S F, et al.Expression of recombinant hyaluronidase from Streptococcus zooepidemicus in Escherichia coli and its enzyme activity[J].Chinese Journal of Pharmaceuticals, 2015, 46(11):1173-1177.
[76] DE-BONA E, CHAVES-MOREIRA D, BATISTA T B D, et al.Production of a novel recombinant brown spider hyaluronidase in baculovirus-infected insect cells[J].Enzyme and Microbial Technology, 2021, 146:109759.
[77] JIN P, KANG Z, YUAN P H, et al.Production of specific-molecular-weight hyaluronan by metabolically engineered Bacillus subtilis 168[J].Metabolic Engineering, 2016, 35:21-30.
