Abstract: Tea polyphenols exhibited various biological and pharmacological effects on cancer prevention. However, they were easily oxidized in the air, which restricted its long-term effects. Encapsulation technology was one of the most effective methods to overcome these drawbacks. Tumor endovascular embolization therapy could block the nutrients and oxygen for tumor cell proliferation and inhibited tumor growth through microcapsule embolization. Meanwhile, the magnetic microcapsule released anti-cancer drugs into the target area to kill cancer cells. Due to little side effects and remarkable therapeutic effects, this therapy was regarded as a new method to treat cancer. The properties of magnetic microcapsules, such as encapsulation efficiency and particle size, were affected by many factors. This study optimized the formula of tea polyphenol magnetic microcapsules by using the experimental design of BBD-RSM. The optimal formula for the preparation of magnetic microcapsules was as follows: the concentration of sodium carboxymethyl cellulose was 1.863 9%, the voltage was 6.222 kV and the propulsion speed was 80 mm/h, respectively. The encapsulation efficiency of magnetic microcapsules was 87.836 2% and the average particle size was 217.67 μm. The magnetic microcapsules had good antioxidant property, and the release of the magnetic microcapsules was sustained for more than 20 h. The result of functional verification showed that the optimized magnetic microcapsules had better slow-release performance and anti-oxidation property.
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