Abstract: An analytical method for the accurate determination of multiple heavy metal elements in aquatic product by inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) was established. For the spectral interferences caused by complex matrices in ICP-MS/MS analysis, O2 was introduced into the octopole reaction system (ORS) as the reaction gas in the MS/MS mode. The analyte Cr+, Ni+, and As+ could react with O2 to form CrO+, NiO+, and AsO+, respectively. While interference ions did not react with O2, the O2 mass shift method was used to eliminate the spectral interferences. Using Sc, In, and Bi as internal standard elements, the matrix effect was corrected and the drift of the analysis signal was prevented. The interference free determination of trace heavy metal elements Cr, Ni, As, Cd, Hg, and Pb in aquatic product was realized. The accuracy of the method proposed was evaluated by analysis of scallop composition analysis certified reference material (GBW10024). The detection limits of analytes ranged from 0.85 to 4.28 ng/L. The relative standard deviation (RSD) was ≤4.65%. Thus, ICP-MS/MS operated in the reaction mode was an effective instrumental strategy for overcoming spectral interferences, which allows the accurate determination of multiple heavy metal elements in aquatic product at trace levels.
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2020, Vol. 46 
