Recent advances on the inhibition of plant-derived natural products on Aspergillus flavus and aflatoxin B1 formation
XIE Jiayu1, ZHANG Wen1, OU Jie1,2,3*
1(College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China) 2(Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China) 3(Laboratory of Quality & Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture and Rural Affairs, Shanghai 201306, China)
Abstract: Aflatoxin B1 (AFB1) is one of the most carcinogenic chemicals, which has a great threat to human and animal health, especially to liver damage.AFB1 is the most common mycotoxin in cereals and oils, and it is also the most harmful one.And the long-term and low-dose intake of AFB1 will not only cause liver damage and induce liver cancer, but also damage other organs of the human body.Therefore, functional foods and new health medicine that can effectively protect human body from AFB1 damage have become a research focus.In recent years, natural products have attracted much attention due to their advantages of significant biological activities, low side effects and multi-target effects.A variety of natural products of plant origin have been reported to be able to inhibit the growth and toxin production of Aspergillus flavus and the toxic effects of AFB1.In this article, we reviewed the inhibition of plant-derived natural products on the growth and toxicity of Aspergillus flavus and the toxicity of AFB1, as well as the related inhibition mechanism, which will hopefully provide a reference for further research on the protection of AFB1 toxic injury and the development of new health care drugs and functional food that can reduce the toxic injury of AFB1 to human and animals.
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