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食品与发酵工业  2021, Vol. 47 Issue (1): 317-326    DOI: 10.13995/j.cnki.11-1802/ts.024563
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植物源天然产物对黄曲霉和黄曲霉毒素B1的抑制作用研究进展
谢佳雨1, 张雯1, 欧杰1,2,3*
1(上海海洋大学 食品学院,上海,201306)
2(上海水产品加工及贮藏工程技术研究中心,上海,201306)
3(农业农村部水产品贮藏保鲜质量安全风险评估实验室(上海),上海,201306)
Recent advances on the inhibition of plant-derived natural products on Aspergillus flavus and aflatoxin B1 formation
XIE Jiayu1, ZHANG Wen1, OU Jie1,2,3*
1(College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China)
2(Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China)
3(Laboratory of Quality & Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture and Rural Affairs, Shanghai 201306, China)
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摘要 黄曲霉毒素B1(aflatoxin B1,AFB1)是化学物质中致癌性最强的一种,对人和动物的健康具有极大的威胁,尤其是对肝脏的损害。AFB1是谷物和粮油中最为多见的真菌毒素,危害性也最强,长期低剂量的摄入AFB1除了会导致肝脏损伤和诱发肝癌之外,也会损害人体的其他器官。因此,能够有效防护人体免遭AFB1损伤的功能食品和新型保健药物已成为研究重点。近年来,天然产物因其具有生物活性显著、副作用小、多靶点等优点而备受关注,多种植物源天然产物已被报道能够抑制黄曲霉的生长产毒和AFB1的毒性作用。该文主要综述了植物源天然产物对黄曲霉生长产毒和AFB1毒性作用的抑制作用以及其相关抑制机制,为进一步开展AFB1毒性损伤的防护研究工作,开发能降低AFB1对人和动物的毒性损伤的新型保健药物和功能食品提供参考。
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谢佳雨
张雯
欧杰
关键词:  天然产物  黄曲霉  黄曲霉毒素B1  生物活性  抑制机制    
Abstract: Aflatoxin B1 (AFB1) is one of the most carcinogenic chemicals, which has a great threat to human and animal health, especially to liver damage.AFB1 is the most common mycotoxin in cereals and oils, and it is also the most harmful one.And the long-term and low-dose intake of AFB1 will not only cause liver damage and induce liver cancer, but also damage other organs of the human body.Therefore, functional foods and new health medicine that can effectively protect human body from AFB1 damage have become a research focus.In recent years, natural products have attracted much attention due to their advantages of significant biological activities, low side effects and multi-target effects.A variety of natural products of plant origin have been reported to be able to inhibit the growth and toxin production of Aspergillus flavus and the toxic effects of AFB1.In this article, we reviewed the inhibition of plant-derived natural products on the growth and toxicity of Aspergillus flavus and the toxicity of AFB1, as well as the related inhibition mechanism, which will hopefully provide a reference for further research on the protection of AFB1 toxic injury and the development of new health care drugs and functional food that can reduce the toxic injury of AFB1 to human and animals.
Key words:  natural products    Aspergillus flavus    aflatoxin B1    biological activity    inhibition mechanism
收稿日期:  2020-05-26      修回日期:  2020-07-05                发布日期:  2021-02-03      期的出版日期:  2021-01-15
基金资助: 国家重点研发计划项目(2018YFC1602205)
作者简介:  硕士研究生(欧杰教授为通讯作者,E-mail:jou@shou.edu.cn)
引用本文:    
谢佳雨,张雯,欧杰. 植物源天然产物对黄曲霉和黄曲霉毒素B1的抑制作用研究进展[J]. 食品与发酵工业, 2021, 47(1): 317-326.
XIE Jiayu,ZHANG Wen,OU Jie. Recent advances on the inhibition of plant-derived natural products on Aspergillus flavus and aflatoxin B1 formation[J]. Food and Fermentation Industries, 2021, 47(1): 317-326.
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