Abstract: Asimple and highly sensitive resonance light scattering method for the detection of antiviral drug residue—lamivudine in fresh livestock and poultry meat was established. In a weak alkaline solution, congo red-cetylpyridinium bromide reacted with lamivudine to form an ionic association complex, which significantly enhanced the resonance light scattering signal and produced a new spectrum with multiple resonance light scattering peaks. At the largest characteristic scattering peak which was presented at 398 nm), the mass concentration of lamivudine in the range of 0.006—0.28 mg/L was linearly related to the enhanced intensity of the resonance light scattering of the association complex. The detection limit was 9.5 μg/kg and the quantitative limit was 0.032 mg/kg. The method was used for the determination of lamivudine in fresh pork and chicken, the spike recovery rate was 96.5%-103% and the relative standard deviation was 1.2%-3.5% (n=5). The method was simple and sensitive, and it can be used for the determination of residues lamivudine in livestock and poultry meat.
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2020, Vol. 46 
