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食品与发酵工业  2021, Vol. 47 Issue (1): 155-159    DOI: 10.13995/j.cnki.11-1802/ts.025185
  研究报告 本期目录 | 过刊浏览 | 高级检索 |
酸枣仁提取物与茶氨酸复合配方对睡眠的改善作用
陈琼*, 陈朋, 李俊颖, 徐旻珺
(仙乐健康科技股份有限公司,广东 汕头,515041)
Sleeping quality improvement by Semen Ziziphi Spinosae and theanine compound formula
CHEN Qiong*, CHEN Peng, LI Junying, XU Minjun
(SIRIO PHARMA CO., LTD., Shantou 515041, China)
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摘要 为探究酸枣仁提取物与茶氨酸的复合配方对小鼠睡眠的影响及其作用机理,将雄性Balb-c小鼠随机分成3组,酸枣仁提取物、茶叶茶氨酸低剂量组[酸枣仁提取物105 mg/(kg·d)、茶氨酸58 mg/(kg·d)]和高剂量组[酸枣仁提取物158 mg/(kg·d)、茶氨酸87 mg/(kg·d)],以及对照组(蒸馏水),连续灌胃30 d,测定各项睡眠指标以及血液和脑组织中各项指标。结果显示,与对照组相比,低剂量组与高剂量组小鼠催眠实验入睡率显著增加,脑组织中5-羟色胺浓度显著提高,β-内啡肽的浓度显著降低。此外,高剂量组小鼠睡眠时间显著延长(P<0.01),睡眠潜伏期显著缩短(P<0.01),血液中色氨酸的浓度显著提高(P<0.05)。以上结果表明,酸枣仁与茶氨酸复合配方,当酸枣仁提取物剂量为158 mg/(kg·d),茶氨酸剂量为87 mg/(kg·d)时,具有改善睡眠的作用,这可能是通过影响小鼠血液中色氨酸,脑中5-羟色胺和β-内啡肽浓度实现的。
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陈琼
陈朋
李俊颖
徐旻珺
关键词:  酸枣仁  茶氨酸  改善睡眠  5-羟色胺  β-内啡肽    
Abstract: To investigate the effect of the compound formula of Semen Ziziphi Spinosae extract and theanine on mice’s sleeping quality and its mechanism. Male Balb-c mice were randomly divided into 3 groups, low-dose group (Semen Ziziphi Spinosae extract: 105 mg/(kg·d), theanine: 58 mg/(kg·d), high-dose group (Semen Ziziphi Spinosae extract: 158 mg/(kg·d), theanine: 87 mg/(kg·d), and control group (distilled water) for 30 d continuous intragastric administration. The sleeping indicators and some indexes in blood and brain tissue were measured. The results showed that, compared with the control group, the hypnotic test sleep rate and the brain 5-hydroxytryptamine concentration were significantly increased, while the brain β-endorphin concentration was significantly decreased both in low-dose group and high-dose group. Besides, mice in the high-dose group had prolonged sleeping time (P<0.01), shortened sleeping latency (P<0.01), and higher blood tryptophan concentrations (P<0.05) compared to the control group. The results suggested that Semen Ziziphi Spinosae extract and theanine compound formula improved the sleeping quality with a dose of 158 mg/(kg·d) Semen Ziziphi Spinosae extract and 87 mg/(kg·d) theanine. It may be achieved by affecting the tryptophan concentration in mouse blood, the 5-hydroxytryptamine concentration and β-endorphin concentration in mouse brain.
Key words:  Semen Ziziphi Spinosae    theanine    sleep improvement    5-hydroxytryptamine    β-endorphin
收稿日期:  2020-07-28      修回日期:  2020-09-15                发布日期:  2021-02-03      期的出版日期:  2021-01-15
作者简介:  硕士,副主任药师(通讯作者,E-mail:806352951@qq.com)
引用本文:    
陈琼,陈朋,李俊颖,等. 酸枣仁提取物与茶氨酸复合配方对睡眠的改善作用[J]. 食品与发酵工业, 2021, 47(1): 155-159.
CHEN Qiong,CHEN Peng,LI Junying,et al. Sleeping quality improvement by Semen Ziziphi Spinosae and theanine compound formula[J]. Food and Fermentation Industries, 2021, 47(1): 155-159.
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http://sf1970.cnif.cn/CN/10.13995/j.cnki.11-1802/ts.025185  或          http://sf1970.cnif.cn/CN/Y2021/V47/I1/155
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