Improving effect of mussel (Mytilus corusus) polysaccharide on dextran sodium sulfate-induced colitis
YAO Liwen1,2, ZHOU Yufang2, SUN Jipeng2, Wang Jiaxing2, LIAO Miaofei2, ZHENG Bin1,2, WANG Rui3, DENG Shanggui1*, XIANG Xingwei2,3*
1(College of Food and Pharmacy,Zhejiang Ocean University,Zhoushan 316021,China) 2(Zhejiang Marine Development Institute,Zhoushan 316021,China) 3(College of Food Science and Technology,Zhejiang University of Technology,Hangzhou 310014,China)
Abstract: In this experiment, three groups:blank control group, model group and Mytilus coruscus polysaccharide (MP) group (300 mg/kg) were set up to explore whether MP could improve colitis induced by dextran sodium sulfate (DSS).After 3.5% DSS was given in daily drinking water, the drug was administrated by gavage, and the improvement effects of MP on colitis in mice were studied by observing the body characterization of mice, intestinal tissue morphology, and determination of intestinal and serum cytokines.The results showed that compared with the model group, the MP group could significantly alleviate the weight loss of mice, the shortening of the colon length (P<0.05), and reduce the disease activity index, improve inflammatory cell infiltration, glandular edema and goblet cell cut back.Compared with the model group, the superoxide dismutase (SOD) and glutathione reductase (GSH-Px) in the colon tissue of the MP group and the GSH-Px activity in the serum were significantly increased (P<0.05), and the SOD in the serum increased but there was no significant difference.The content of inflammatory factor tumor necrosis factor-ɑ(TNF-ɑ)in colon tissue and serum was significantly reduced (P<0.05), and the content of interleukin-6(IL-6)was reduced but there was no significant difference.The results proved that the Mytilus coruscus polysaccharide could improve the colitis induced by DSS to a certain extent.
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2021, Vol. 47 
