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食品与发酵工业  2021, Vol. 47 Issue (7): 269-277    DOI: 10.13995/j.cnki.11-1802/ts.025675
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植物多糖对肾损伤干预效果及作用机制研究进展
刘婷1,2,3,4, 周欣1,2,3,4, 赵超1,2,3,4, 龚小见1,2,3,4, 陈华国1,2,3,4*
1(贵州师范大学 贵州省山地环境信息系统与生态环境保护重点实验室,贵州 贵阳,550001)
2(贵州师范大学 喀斯特山地生态环境保护与资源利用协同创新中心,贵州 贵阳,550001)
3(贵州师范大学 贵州省药物质量控制及评价技术工程实验室,贵州 贵阳,550001)
4(贵州师范大学 天然药物质量控制研究中心,贵州 贵阳,550001)
Research progress on plant polysaccharides against kidney injury and its mechanism
LIU Ting1,2,3,4, ZHOU Xin1,2,3,4, ZHAO Chao1,2,3,4, GONG Xiaojian1,2,3,4, CHEN Huaguo1,2,3,4*
1(Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment,Guizhou Normal University,Guiyang 550001,China)
2(Collaborative Innovation Center for Karst Mountain Ecological Environmental Protection and Resource Utilization (Project of Education Department of Guizhou Province),Guizhou Normal University,Guiyang 550001,China)
3(Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine,Guizhou Normal University,Guiyang 550001,China)
4(Research Center for Quality Control of Natural Medicine,Guizhou Normal University,Guiyang 550001,China.)
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摘要 植物多糖作为一种食物来源,往往以膳食纤维的形式对人体产生有益的影响,有效抗肾脏损伤是其重要的作用之一。目前对于肾脏病的预防与治疗主要以药物为主,对于保健品、功能性食品等辅助治疗肾脏病的研究报道较少。该文从食品角度简述了植物多糖对糖尿病肾损伤、缺血再灌注肾损伤、重金属肾损伤、化学性肾损伤和药物性肾损伤的干预效果,并从直接和间接两个方面着重探讨了多糖发挥抗肾损伤的作用机制,进一步对植物多糖抗肾损伤的研究方向进行展望,以期为研发干预肾损伤的功能性食品提供参考。
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刘婷
周欣
赵超
龚小见
陈华国
关键词:  肾损伤  植物多糖  氧化应激  炎症  信号通路    
Abstract: As a kind of food resource, the plant polysaccharides have many beneficial effects on human body in the form of dietary fiber, and it is also an effective anti-kidney damage agent. At present, the prevention and treatment of kidney disease are mainly based on drugs. However, there are also research on the supplementary treatment of kidney diseases using health products and functional foods. In this review, the intervention effects of plant polysaccharides on diabetic kidney injury, ischemia-reperfusion kidney injury, heavy metal kidney injury, chemical kidney injury, and drug-induced kidney injury from the food point of view were briefly reviewed, and the mechanisms of polysaccharides against kidney injury from both direct and indirect aspects were mainly discussed. Finally, the research direction of plant polysaccharides against kidney damage have further prospected, so as to provide a reference for the development of functional foods for the treatment of kidney injury.
Key words:  kidney injury    plant polysaccharides    oxidative stress    inflammation    signalling pathway
收稿日期:  2020-09-16      修回日期:  2020-10-26           出版日期:  2021-04-15      发布日期:  2021-05-20      期的出版日期:  2021-04-15
基金资助: 贵州省科技计划项目(黔科合平台人才[2017]5625);贵州省普通高等学校科技拔尖人才支持计划项目(黔教合 KY字[2017]065);贵州省高层次创新人才培养项目(黔科合人才[2015]4033);贵州省科技计划项目(黔科合支撑[2018]2826)
作者简介:  硕士研究生(陈华国教授为通讯作者,chenhuaguo01981@163.com)
引用本文:    
刘婷,周欣,赵超,等. 植物多糖对肾损伤干预效果及作用机制研究进展[J]. 食品与发酵工业, 2021, 47(7): 269-277.
LIU Ting,ZHOU Xin,ZHAO Chao,et al. Research progress on plant polysaccharides against kidney injury and its mechanism[J]. Food and Fermentation Industries, 2021, 47(7): 269-277.
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http://sf1970.cnif.cn/CN/10.13995/j.cnki.11-1802/ts.025675  或          http://sf1970.cnif.cn/CN/Y2021/V47/I7/269
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