Abstract: Zearalenone and its derivatives are the most widely-existed mycotoxins around the world, causing huge safety hazards and economic losses to humans.Traditional physical and chemical detoxification methods cannot meet the demands of industrial applications due to their incomplete detoxification, destruction to food texture, and loss of nutrients.In recent years, biological and enzymatic degradation of mycotoxins has gradually been studied and reported due to its wide range of microbial sources, mild enzyme reaction conditions and high detoxification efficiency.Particularly, the lactone has been extensively studied due to its high ZEN degradation activity, clear detoxification mechanism, irreversible detoxification process and elucidated crystal structure.This article reviewed the research progress of lactone in terms of gene mining, characterization, molecular modification and application exploration.The purpose is to clarify the advantages and challenges in the industrial application of the zearalenone-detoxifying lactone, and provide certain references for its future research on zearalenone biodegradation.
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