Abstract: DP1, DP2 and DP3 were prepared from crude polysaccharide by ethanol fractional precipitation chromatography. The hypoglycemic activity of polysaccharides from dandelion root was studied by cell and animal experiments. The results showed that DP2 had the best hypoglycemic effect. All the three polysaccharides could improve the glucose tolerance of diabetic mice, and DP2 had the best effect. Compared with the model group, the contents of TC, TG and LDL-C in the polysaccharide intervention group were significantly decreased, while the content of HDL-C was significantly increased which indicating that the three components had benefit on dyslipidemia. In addition, dandelion root polysaccharide had a certain protective effect on the liver. The liver glycogen content of DP1 was the highest in type 2 diabetic mice and the glucose consumption of DP2 was the highest in HepG2 insulin resistance model. While, DP3 showed obvious protective effect on damaged islet cells. Based on these results, it could speculate that the molecular structure of the three kinds of dandelion root polysaccharides was different, which makes them have different hypoglycemic effects.
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2021, Vol. 47 
