Please wait a minute...
 
 
食品与发酵工业  2021, Vol. 47 Issue (9): 275-283    DOI: 10.13995/j.cnki.11-1802/ts.026251
  综述与专题评论 本期目录 | 过刊浏览 | 高级检索 |
黄酒多糖对炎症性肠病及便秘作用机制的研究进展
史瑛1,2, 冯欣静1,2, 周志磊1,2, 姬中伟1,2, 徐岳正3, 毛健1,2*
1(粮食发酵工艺与技术国家工程实验室(江南大学),江苏 无锡,214122)
2(江南大学 食品学院,江苏 无锡,214122)
3(国家黄酒工程技术研究中心,浙江 绍兴,312000)
Research progress on the mechanism of Huangjiu polysaccharides on inflammatory bowel disease and constipation
SHI Ying1,2, FENG Xinjing1,2, ZHOU Zhilei1,2, JI Zhongwei1,2, XU Yuezheng3, MAO Jian1,2*
1(National Engineering Laboratory for Cereal Fermentation Technology,Jiangnan University,Wuxi 214122,China)
2(School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)
3(National Engineering Research Center of Chinese Rice Wine,Shaoxing 312000,China)
下载:  HTML  PDF (1397KB) 
输出:  BibTeX | EndNote (RIS)      
摘要 独特的酿造体系及低温长时的酿造工艺赋予了黄酒丰富的生物活性物质,多糖作为黄酒中主要的生物活性成分,含量丰富,种类独特,具有平衡肠道菌群、改善肠内环境等功效。由于黄酒多糖组分复杂,难以提取专一成分进行靶向研究,目前针对黄酒多糖的功能研究主要集中于调节肠道菌群,对其他肠道疾病的影响及其作用机制尚未明确。该文论述了黄酒多糖的来源、提取工艺、结构分析,并阐述了黄酒多糖等膳食多糖对机体肠道屏障的维护、便秘症状的缓解及炎症性肠病的治疗机理,为黄酒多糖的后续功能研究提供了理论基础与新的思路。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
史瑛
冯欣静
周志磊
姬中伟
徐岳正
毛健
关键词:  黄酒多糖  肠道菌群  肠道屏障  便秘  炎症性肠病    
Abstract: As one of the national wines in China, Huangjiu (Chinese rice wine) has a brewing history of thousands of years. The abundant bioactive compounds in Huangjiu are processed during low-temperature and long-term brewing under the unique multi-species involved fermentation system. Polysaccharides are essential bioactive components in Huangjiu, which have effects in restoration of gut microbiota and improvement of intestinal ecology. It is relatively difficult to extract specific polysaccharide components for targeted research due to the complex components in Huangjiu polysaccharides. Recent studies mainly focused on the function of Huangjiu polysaccharides in regulation of gut microbiota, while the effects and mechanisms of Huangjiu polysaccharides on intestinal diseases remain unknown. This review summarizes the original source, extraction methods and the structural analysis of Huangjiu polysaccharides, as well as the mechanisms of dietary polysaccharides including Huangjiu polysaccharides on the maintenance of intestinal barrier, alleviation of constipation symptoms and treatment of inflammatory bowel disease. The review is expected to provide theoretical basis and new insights for study on the function of Huangjiu polysaccharides.
Key words:  Huangjiu polysaccharide    gut microbiota    intestinal barrier    constipation    inflammatory bowel disease
收稿日期:  2020-11-23      修回日期:  2020-12-26           出版日期:  2021-05-15      发布日期:  2021-06-03      期的出版日期:  2021-05-15
基金资助: 国家重点研发计划项目(2018YFD0400401);国家自然科学基金项目(32001710);国家轻工技术与工程一流学科自主命题(LITE2 018-13);中国博士后科学基金站前特别资助项目(2019TQ0122),江苏省自然科学基金青年基金项目(BK20200600)
作者简介:  博士,助理研究员(毛健教授为通讯作者,E-mail:maojian@jiangnan.edu.cn)
引用本文:    
史瑛,冯欣静,周志磊,等. 黄酒多糖对炎症性肠病及便秘作用机制的研究进展[J]. 食品与发酵工业, 2021, 47(9): 275-283.
SHI Ying,FENG Xinjing,ZHOU Zhilei,et al. Research progress on the mechanism of Huangjiu polysaccharides on inflammatory bowel disease and constipation[J]. Food and Fermentation Industries, 2021, 47(9): 275-283.
链接本文:  
http://sf1970.cnif.cn/CN/10.13995/j.cnki.11-1802/ts.026251  或          http://sf1970.cnif.cn/CN/Y2021/V47/I9/275
[1] MENG X,ZHANG G,CAO H,et al.Gut dysbacteriosis and intestinal disease:Mechanism and treatment[J].Journal of Applied Microbiology,2020,129(4):787-805.
[2] BELORKAR S A,GUPTA A K.Oligosaccharides:A boon from nature's desk[J].AMB Express,2016,6(1):82.
[3] KURASHIMA Y,KIYONO H.Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing[J].Annual Review of Immunology,2017,35:119-147.
[4] 周欣,付志飞,谢燕,等.中药多糖对肠道菌群作用的研究进展[J].中成药,2019,41(3):623-627.
ZHOU X,FU Z F,XIE Y,et al.Research progress on the effects of polysaccharides from traditional Chinese medicine on intestinal flora[J].Chinese Traditional Patent Medicine,2019,41(3):623-627.
[5] VERA C,UBILLA C,GUERRERO C,et al.Non-digestible oligosaccharides and polysaccharides:A source of health for older people[J].Revista Chilena de Nutricion,2020,47(5):848-864.
[6] 李琴.黄酒中多糖稳定性的研究[D].杭州:浙江农林大学,2017.
LI Q.Study on the stability of polysaccharide in yellow rice wine[D].Hangzhou:Zhejiang A&F University,2017.
[7] 邵胜男,于中玉.黄酒酿造工艺现状及行业发展[J].吉林农业,2015(23):116-116.
SHAO S N,YU Z Y.Current situation and industry development of Chinese rice wine brewing technology[J].Agriculture of Jilin,2015(23):116-116.
[8] 孟祥勇,沈赤,毛健,等.黄酒多糖的分离纯化及理化性质研究[J].食品与生物技术学报,2017,36(10):1 029-1 035.
MENG X Y,SHEN C,MAO J,et al.Isolation,purification and physicochemical properties of polysaccharides from Chinese rice wine[J].Journal of Food Science and Biotechnology,2017,36(10):1 029-1 035.
[9] 彭昭君.小麦芽木聚糖内切酶的纯化鉴定及对小麦源阿拉伯木聚糖的降解特性[D].泰安:山东农业大学,2020.
PENG Z J.Purification,identification and degradation characterization on wheat-derived arabinoxylan of an endo-xylanase from wheat malt[D].Tai'an:Shandong Agricultural University,2020.
[10] 张斌. 小麦芽内切-β-(1,4)-D-木聚糖酶对麸皮中水溶性木聚糖降解作用[D].泰安:山东农业大学,2016.
ZHANG B.The effect of endo-β-(1,4)-D-xylanase by wheat malt on water-extractble arabinoxylan degradation in wheat bran[D].Tai'an:Shandong Agricultural University,2016.
[11] LU Q Y,LEE R P,HUANG J J,et al.Quantification of bioactive constituents and antioxidant activity of Chinese yellow wine[J].Journal of Food Composition and Analysis,2015,44:86-92.
[12] 陈传平, 陈乃东,陈红风.柱前衍生-高效毛细管电泳法分析不同黄酒的多糖组成[J].食品工业科技,2018,39(8):221-225.
CHEN C P,CHEN N D,CHEN H F.Analysis of polysaccharides in different yellow rice wine by pre-column derivatization and high performance capillary electrophoresis[J].Science and Technology of Food Industry,2018,39(8):221-225.
[13] 刘晓艳, 李湘銮,白卫东,等.客家黄酒多糖的分离纯化及结构表征[J].仲恺农业工程学院学报,2020,33(1):38-43.
LIU X Y,LI X L,BAI W D,et al.Purification and structural characterization of polysaccharides from Hakka rice wine[J].Journal of ZhongKai University of Agriculture and Technology,2020,33(1):38-43.
[14] 彭金龙, 毛健,黄桂东,等.黄酒多糖体外抗氧化活性研究[J].食品工业科技,2012,33(20):94-97.
PENG J L,MAO J,HUANG G D,et al.Study on antioxidant activity of polysaccharide from Chinese rice wine in vitro[J].Science and Technology of Food Industry,2012,33(20):94-97.
[15] 王光强, 张莹,黄晨蕾,等.黄酒中多糖的提取和分析[J].工业微生物,2018,48(1):1-7.
WANG G Q,ZHANG Y,HUANG C L,et al.Extraction and analysis of polysaccharide from yellow rice wine[J].Industrial Microbiology,2018,48(1):1-7.
[16] 朱怡卿, 刘玮,王虹,等.多糖对肠道功能调节作用的研究进展[J].药学进展,2015,39(4):293-299.
ZHU Y Q,LIU W,WANG H,et al.Advances in researches on regulatiry effeet of polysaccharides on intestinal tract function[J].Progress in Pharmaceutical Sciences,2015,39(4):293-299.
[17] CHEN D,CHEN G,CHEN C,et al.Prebiotics effects in vitro of polysaccharides from tea flowers on gut microbiota of healthy persons and patients with inflammatory bowel disease[J].International Journal of Biological Macromolecules,2020,158:968-976.
[18] XIE S Z,LIU B,YE H Y,et al.Dendrobium huoshanense polysaccharide regionally regulates intestinal mucosal barrier function and intestinal microbiota in mice[J].Carbohydrate Polymers,2019,206:149-162.
[19] CARLSON J L,ERICKSON J M,LLOYD B B,et al.Health effects and sources of prebiotic dietary fiber[J].Current Developments in Nutrition,2018,2(3):nzy005.
[20] FARHOOD B,NAJAFI M,MORTEZAEE K.CD8+ cytotoxic Tlymphocytes in cancer immunotherapy:A review[J].Journal of Cellular Physiology,2019,234(6):8 509-8 521.
[21] 段晓芸,周芹,杨芃,等.术前口服葡萄糖溶液对结直肠肿瘤术后肠黏膜屏障功能的保护作用[J].中华普通外科学文献(电子版),2012,6(6):495-499.
DUAN X Y,ZHOU Q,YANG P,et al.Effects of preoperative oral glucose solution on postoperative intestinal barrier function after colorectal cancer surgery[J].Chinese Archives of General Surgery (Electronic Edition),2012,6(6):495-499.
[22] 张晓音,赵圣国,骆超超,等.岩藻糖介导微生物与肠道上皮细胞的互作及其机制[J].动物营养学报,2018,30(7):2 473-2 479.
ZHANG X Y,ZHAO S G,LUO C C,et al.Fucose mediated interaction between microorganisms and intestinal epithelial cells and its mechanism[J].Chinese Journal of Animal Nutrituon,2018,30(7):2 473-2 479.
[23] 白婧.甘露糖对大鼠重症急性胰腺炎及肠粘膜屏障损伤的保护作用[D].石家庄:河北医科大学,2013.
BAI J.The effect of mannose on the intestinal mucosal barrier dysfunction of severe acute pancreatitis in rats[D].Shijiazhuang:Hebei Medical University,2013.
[24] 张行.L-阿拉伯糖对身体机能影响的研究[J].当代体育科技,2019,9(14):11;3.
ZHANG X.Effect of L-arabinose on body function[J].Contemporary Sports Technology,2019,9(14):11;3.
[25] 欧阳海燕.木糖及低聚木糖对鼠伤寒沙门氏菌增殖及其粘附性的调控[D].广州:华南农业大学,2017.
OUYANG H Y.Effects of xylose,xylo-oligosaccharides on the Salmonella typhimurium proliferation and the adhesion[D].Guangzhou:South China Agricultural University,2017.
[26] MASUI R,SASAKI M,FUNAKI Y,et al.G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells[J].Inflammatory Bowel Diseases,2013,19(13):2 848-2 856.
[27] HAN X,BAI B Y,ZHOU Q,et al.Dietary supplementation with polysaccharides from Ziziphus Jujuba cv. intervenes in immune response via regulating peripheral immunity and intestinal barrier function in cyclophosphamide-induced mice[J].Food & Function,2020,11(7):5 992-6 006.
[28] SUZUKI T.Regulation of intestinal epithelial permeability by tight junctions[J].Cellular and Molecular Life Sciences,2013,70(4):631-659.
[29] YING M X,ZHENG B,YU Q,et al.Ganoderma atrum polysaccharide ameliorates intestinal mucosal dysfunction associated with autophagy in immunosuppressed mice[J].Food and Chemical Toxicology,2020,138:111 244.
[30] YING M X,YU Q,ZHENG B,et al.Cultured Cordyceps sinensis polysaccharides attenuate cyclophosphamide-induced intestinal barrier injury in mice[J].Journal of Functional Foods,2019,62:103 523.
[31] SBAHI H,CASH B D.Chronic constipation:A review of current literature[J].Current Gastroenterology Reports,2015,17(12):1-13.
[32] ADAMS-CARR K L,BESTWICK J P,SHRIBMAN S,et al.Constipation preceding Parkinson's disease:A systematic review and meta-analysis[J].Journal of Neurology Neurosurgery and Psychiatry,2016,87(7):710-716.
[33] 史益凡.短链脂肪酸含量对顽固性便秘病人结肠动力的影响及机理[D].南京:南京大学,2016.
SHI Y F.The effect and mechanism of short-chain fatty acid content on colonic motility in patients with refractory constipation[D].Nanjing:Nanjing University,2016.
[34] 刘响,曹海龙,安莹莹,等.慢性便秘患者肠道菌群对小鼠肠道5-羟色胺转运体表达及排便功能的影响[J].中华消化杂志,2017,37(6):399-403.
LIU X,CAO H L,AN Y Y,et al.Effect of intestinal flora on expression of serotonin transporter and defecation function in mice with chronic constipation[J].Chinese Journal of Digestion,2017,37(6):399-403.
[35] 史先振,朱圣陶,贺峰.木糖改善胃肠道保健功能的实验研究[J].食品与药品,2008,10(9):40-42.
SHI X Z,ZHU S T,HE F.Experimental study on xylose improving gastrointestinal health function by xylose[J].Food and Drug,2008,10(9):40-42.
[36] 甘激文.L-岩藻糖的性质、应用及市场前景[J].大众科技,2019,21(12):14-16.
GAN J W.Properties,application and market prospect of L-fucose[J].Popular Science & Technology,2019,21(12):14-16.
[37] 王浩.甘露糖对溃疡性结肠炎相关结直肠癌变的预防作用及机制初步探究[D].无锡:江南大学,2020.
WANG H.Preventive effect and mechanism of mannose on ulcerative colitis associated colorectal cancer[D].Wuxi:Jiangnan University,2020.
[38] 何智勇,于俊兰,尹剑,等.50%葡萄糖注射液局部注射治疗老年出口梗阻型便秘的临床疗效[J].中国肛肠病杂志,2014,34(10):55-56.
HE Z Y,YU J L,YIN J,et al.Clinical efficacy of 50% glucose injection in the treatment of elderly patients with outlet obstruction constipation[J].Chinese Journal of Coloproctology,2014,34(10):55-56.
[39] 牛英颖.垂丝海棠花多糖改善功能性便秘及增强免疫力评价[D].开封:河南大学,2019.
NIU Y Y.Polysaccharides extracted from Malus halliana koehne flowers to improve constipation and enhance immunity evaluation[D].Kaifeng:Henan University,2019.
[40] XIN X,ZHENG K W,NIU Y Y,et al.Effect of Flammulina velutipes (golden needle mushroom,eno-kitake) polysaccharides on constipation[J].Open Chemistry,2018,16(1):155-162.
[41] 苗晶囡,邱军强,李海霞,等.天然多糖对肠道菌群调节作用的研究进展[J].中国食物与营养,2019,25(12):52-58.
MIAO J N,QIU J Q,LI H X,et al.Research progress on regulation of natural polysaccharides on intestinal flora[J].Food and Nutrition in China,2019,25(12):52-58.
[42] JIANG H M,DONG J,JIANG S J,et al.Effect of Durio zibethinus rind polysaccharide on functional constipation and intestinal microbiota in rats[J].Food Research International,2020,136:109 316.
[43] LONG C X,HE L,GUO Y F,et al.Effects of Dendrobium candidum polysaccharide on immunity,intestinal microbiota and enzyme activity in mice with spleen deficiency constipation[J].Natural Product Research and Development,2017,29(6):1 020-1 024;1 034.
[44] LANGE K M,BARRETT J C.Understanding inflammatory bowel disease via immunogenetics[J].Journal of Autoimmunity,2015,64:91-100.
[45] 黄菊青,林斌,徐庆贤,等.竹茹多糖体外调节肠道菌群的作用研究[J].营养学报,2019,41(1):45-52.
HUANG J Q,LIN B,XU Q X,et al.In vitro fermentation of polysaccharides from Bamboo shavings by human gut microbiota[J].Acta Nutrimenta Sinica,2019,41(1):45-52.
[46] CHEN R,LIU B,WANG X Y,et al.Effects of polysaccharide from Pueraria iobata on gut microbiota in mice[J].International Journal of Biological Macromolecules,2020,158:740-749.
[47] TANG C,SUN J,ZHOU B,et al.Effects of polysaccharides from purple sweet potatoes on immune response and gut microbiota composition in normal and cyclophosphamide treated mice[J].Food & Function,2018,9(2):937-950.
[48] MONTURIL H P H R,BRITO T V,CRUZ J S D C,et al.Sulfated polysaccharide from Digenea simplex decreases intestinal inflammation in rats[J].Revista Brasileira De Farmacognosia,2020,30(3):388-396.
[49] ZHAO R Q,JI Y,CHEN X,et al.Effects of a β-type glycosidic polysaccharide from Flammulina velutipes on anti-inflammation and gut microbiota modulation in colitis mice[J].Food & Function,2020,11(5):4 259-4 274.
[50] ZHAO D,DAI W J,TAO H,et al.Polysaccharide isolated from Auricularia auricular-judae (Bull.) prevents dextran sulfate sodium-induced colitis in mice through modulating the composition of the gut microbiota[J].Journal of Food Science,2020,85(9):2 943-2 951.
[1] 贾叶, 包斌, 马明, 魏婷. 蚕蛹蛋白源肠内营养混悬剂对二型糖尿病小鼠肠道菌的影响[J]. 食品与发酵工业, 2021, 47(8): 62-66.
[2] 王路, 张蕾, 郑皎碧, 王琼熠, 范辉. 发酵制品调控糖脂代谢性疾病作用机制的研究进展[J]. 食品与发酵工业, 2021, 47(7): 292-300.
[3] 邹仁英, 朱慧越, 许梦舒, 田培郡, 张灏, 赵建新, 陈卫, 王刚. “精神益生菌”对慢性应激诱导的抑郁和便秘症状的缓解及机制研究[J]. 食品与发酵工业, 2021, 47(3): 1-9.
[4] 徐珒昭, 汤梦琪, 徐境含, 滕国新, 许晓曦. 焦谷氨酸对高盐饮食小鼠肠道健康及肠道菌群的作用[J]. 食品与发酵工业, 2021, 47(2): 102-108.
[5] 孔庆敏, 朱慧越, 田培郡, 赵建新, 张灏, 陈卫, 王刚. 嗜酸乳杆菌La28对丙戊酸暴露引起的子代大鼠外周炎症和肝损伤的缓解作用[J]. 食品与发酵工业, 2021, 47(1): 125-131.
[6] 杨开, 张雅杰, 张酥, 蔡铭, 皮雄娥, 胡君荣, 关荣发, 孙培龙. 灵芝孢子粉低聚糖的制备及调节肠道菌群功能研究[J]. 食品与发酵工业, 2020, 46(9): 37-42.
[7] 赵孟良, 任延靖. 菊粉及其调节宿主肠道菌群机制的研究进展[J]. 食品与发酵工业, 2020, 46(7): 271-276.
[8] 金星, 贺禹丰, 周永华, 陈晓华, 王刚, 赵建新, 张灏, 陈卫. 唾液乳杆菌CCFM 1054通过改变肠道菌群缓解空肠弯曲杆菌在小鼠体内的感染[J]. 食品与发酵工业, 2020, 46(5): 1-8.
[9] 杨树荣, 朱慧越, 乌翛冰, 孙姗姗, 司倩, 张秋香, 王琳琳, 王刚, 赵建新, 张灏, 陈卫. 副干酪乳杆菌缓解由洛哌丁胺诱导的小鼠便秘的差异[J]. 食品与发酵工业, 2020, 46(2): 25-31.
[10] 管玲娟, 曹丛丛, 屠飘涵, 成向荣. 缺铁对肠道免疫功能的影响及新型补铁剂的研究进展[J]. 食品与发酵工业, 2020, 46(19): 264-270.
[11] 刘霞, 黄雅萍, 卢旭, 郑宝东, 缪松, 邓凯波. 抗性淀粉的结构性质与功能关系研究进展[J]. 食品与发酵工业, 2020, 46(18): 279-286.
[12] 张世奇, 唐兰兰, 孙劲毅, 杨娟, 惠永海. 辣椒素降糖作用及其机制研究进展[J]. 食品与发酵工业, 2020, 46(13): 262-269.
[13] 冯潇, 包璇, 向沙沙, 沈宇标, 应轩宇, 应剑, 纪伟, 朱炫. 探究钴卟啉模拟结肠发酵对肠道菌群的调控[J]. 食品与发酵工业, 2020, 46(12): 87-94.
[14] 焦婷, 朱慧越, 司倩, 许梦舒, 孙姗姗, 马方励, 王刚, 赵建新, 张灏, 陈卫. 罗伊氏乳杆菌CCFM8631缓解小鼠非酒精性脂肪性肝病与其对肠道菌群及短链脂肪酸的调节显著相关[J]. 食品与发酵工业, 2020, 46(10): 35-43.
[15] 郑雨星, 朱慧越, 焦婷, 杨树荣, 刘倩, 王刚, 赵建新, 张灏, 陈卫. 鼠李糖乳杆菌FZJTZ46L6通过影响肠道内短链脂肪酸的水平缓解小鼠由葡聚糖硫酸钠导致的结肠炎[J]. 食品与发酵工业, 2020, 46(10): 44-52.
No Suggested Reading articles found!
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
版权所有 © 《食品与发酵工业》编辑部
地址:北京朝阳区酒仙桥中路24号院6号楼111室
本系统由北京玛格泰克科技发展有限公司设计开发  技术支持:support@magtech.com.cn