Abstract: In order to study the regulatory effect of fruit mulberry tea on intestinal microbiota in type 2 diabetes mice model, high-fat diet combined with streptozotocin was used to induce the type 2 diabetic mice model. The feces of mice from different groups were collected to analyze the changes in the microbiota using high-throughput sequencing. The results showed that the occurrence of type 2 diabetes could lead to the imbalance of intestinal microbiota in mice, among which the diversity of intestinal microbiota in the control group was the lowest, the relative abundance of some beneficial bacteria was decreased, and the relative abundance of harmful bacteria was increased. In contrast, fruit mulberry tea powder dose group (GDm group) and fruit mulberry tea extract dose group (GDh group) significantly increased the relative abundance of Muribaculaceae_unclassified, Akkermansia, Lachnospiraceae and other beneficial bacteria, enriching the diversity of bacteria. The intestinal microbiota of the GDm group was the closest to that of the normal control group, and the regulation effect was the most significant. This research proves that fruit mulberry tea can effectively regulate the structure and abundance of intestinal microbiota in type 2 diabetes model mice, promote the benign development of intestinal microbiota, providing theoretical basis for the development of fruit mulberry hypoglycemic health products.
魏建敏,杨华连,陈莉,等. 基于高通量测序分析果桑茶对2型糖尿病模型小鼠肠道菌群的影响[J]. 食品与发酵工业, 2021, 47(20): 75-82.
WEI Jianmin,YANG Hualian,CHEN Li,et al. Effect of fruit mulberry tea on intestinal microbiota of type 2 diabetic mice based on high-throughput sequencing[J]. Food and Fermentation Industries, 2021, 47(20): 75-82.
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