Abstract: The effects of yak bone collagen peptides (YBCP) on the fermentation of mice fecal microbiota were studied by constructing a simulated digestion and fermentation system in vitro. The pH, short-chain fatty acids (SCFA) and lactic acid were detected during the fermentation. At the end of the trial, the composition of gut microbiota was analyzed by 16S rRNA sequencing. The results showed that the concentration of SCFA and lactic acid in the YBCP added groups were significantly increased when compared with that in the control group (P<0.01). The concentration of acetic acid and propionic acid in the high-dose group was increased by 86.7% and 83.7%, respectively. Moreover, species diversity and gut microbiota composition were altered. Compared with the control group, the relative abundance of Actinobacteria in the low-dose and high-dose groups was increased by 69.3% and 52%, respectively. At the genus level, the relative abundance of Bifidobacterium in the low-dose and high-dose groups was elevated by 70.3% and 52.4%, respectively. The predicted functions of the fecal microbiota indicated that the carbohydrate and amino acid metabolism of fecal microbiota in mice had a certain improvement in the YBCP groups. These results indicated that the YBCP might have the ability to modulate the structure of gut microbiota in mice.
刘春雨,衣大龙,杨玉亮,等. 牦牛骨胶原蛋白肽体外调节肠道菌群的研究[J]. 食品与发酵工业, 2021, 47(16): 59-65.
LIU Chunyu,YI Dalong,YANG Yuliang,et al. Modulation effects of yak bone collagen peptides on gut microbiota in vitro[J]. Food and Fermentation Industries, 2021, 47(16): 59-65.
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