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食品与发酵工业  2021, Vol. 47 Issue (21): 94-101    DOI: 10.13995/j.cnki.11-1802/ts.028429
  研究报告 本期目录 | 过刊浏览 | 高级检索 |
黑木耳改善高脂饮食引起的小鼠肥胖及肠道菌群紊乱
祝莉娜1,2,3, 胡锦宏1,2,3, 张婷1,2,3, 岳田利1,2,3, 宋微1,2,3*
1(西北大学 食品学院,陕西 西安,710069)
2(陕西省营养健康食品个性制造工程实验室(西北大学),陕西 西安,710069)
3(陕西省食品安全风险识别控制技术研究中心(西北大学),陕西 西安,710069)
Ameliorating effects of Auricularia auricula on obesity and gut microbiota dysbiosis in mice induced by high fat diet
ZHU Lina1,2,3, HU Jinhong1,2,3, ZHANG Ting1,2,3, YUE Tianli1,2,3, SONG Wei1,2,3*
1(College of Food Science and Technology, Northwest University, Xi’an 710069, China)
2(Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Xi’an 710069, China)
3(Research Center of Food Safety Risk Assessment and Control, Xi’an 710069, China)
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摘要 高糖高脂饮食过量摄入导致脂肪蓄积从而形成肥胖,增加相关慢性疾病的患病率和死亡率。该研究通过膳食补充黑木耳,从而改善高脂饮食引起的小鼠脂肪堆积及肠道菌群紊乱。黑木耳经干燥并粉碎后添加到小鼠高脂饲料中,实验进行4周,每2 d称重1次,最后1周收集粪便以进行肠道菌群高通量测序。小鼠处死后取血清、肝脏、脾脏等进行测定。结果表明,膳食补充黑木耳能显著降低小鼠体重及血清中胆固醇和甘油三酯的含量,同时减少肝脏中的脂滴含量,且日常摄入黑木耳能有效减轻高脂饮食引起的肠道菌群紊乱。综上,膳食补充黑木耳能有效改善高脂饮食引起的小鼠肥胖、肝脏脂质堆积及肠道菌群紊乱。
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祝莉娜
胡锦宏
张婷
岳田利
宋微
关键词:  高脂饮食  肥胖  黑木耳  肠道菌群    
Abstract: Auricularia auricula was added into the high-fat diets (HFD) of mice to ameliorate fat and gut microbiota dysbiosis. The experiment was carried out for four weeks and the mice were weighed on alternate day. Feces were collected for high-throughput sequencing in the last week. After executed, the serum, liver and spleen were collected for determination. The results showed that dietary supplementation of A. auricula significantly reduced the body weight, the content of cholesterol and triglyceride and the content of lipid droplets in liver. Moreover, daily intake of A. auricula effectively alleviated the disturbance of gut microbiota caused by HFD. In conclusion, dietary supplementation of A. auricula effectively ameliorated the obesity, hepatic lipid accumulation and gut microbiota dysbiosis of mice.
Key words:  high fat diet    obesity    Auricularia auricula    gut microbiota
收稿日期:  2021-06-21      修回日期:  2021-07-09           出版日期:  2021-11-15      发布日期:  2021-11-30      期的出版日期:  2021-11-15
基金资助: 国家重点研发计划(2019YFC1606704);国家自然科学基金青年科学基金(31901701)
作者简介:  硕士研究生(宋微副教授为通讯作者,E-mail:weisong2019@nwu.edu.cn)
引用本文:    
祝莉娜,胡锦宏,张婷,等. 黑木耳改善高脂饮食引起的小鼠肥胖及肠道菌群紊乱[J]. 食品与发酵工业, 2021, 47(21): 94-101.
ZHU Lina,HU Jinhong,ZHANG Ting,et al. Ameliorating effects of Auricularia auricula on obesity and gut microbiota dysbiosis in mice induced by high fat diet[J]. Food and Fermentation Industries, 2021, 47(21): 94-101.
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http://sf1970.cnif.cn/CN/10.13995/j.cnki.11-1802/ts.028429  或          http://sf1970.cnif.cn/CN/Y2021/V47/I21/94
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