Abstract: Insomnia is a sort of sleep disorder, which is affected by multiple factors such as neurological/endocrine system disorders, environmental factors, and psychosocial factors. Long-term insomnia can cause chronic fatigue and lack of concentration. More seriously, it can lead to memory decline, mood disorders, and even neurodegenerative diseases. Since current chemotherapeutics have disadvantages such as adverse side effects and insufficient curative effects, it is urgent to develop new prevention and treatment strategies. In recent years, with the in-depth understanding of the microbiome-gut-brain axis, targeting the gut microbiota to regulate the host’s circadian rhythm and the nervous system shows promising flexibility. Thus, this review summarizes the pathological mechanism of insomnia, the role of the gut microbiome in insomnia, and the dietary strategies for alleviating insomnia to guide the development of new anti-insomnia drugs and functional foods.
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2022, Vol. 48 
