Abstract: On the basis of single factor experiment,the parameters of scavenging effect on sodium nitrite by herba epimedii was optimized by response surface methodology(RSM) based on a box-behnken design(BBD).The study showed that the optimum extraction was: ethanol concentration 58%,ratio of material to liquid 1∶ 37;extraction time 176min and extraction temperate 78℃.The maximum capabilities of scavenging was 75.64%.