Abstract: Soy infant formula refers to infant formula food which contains soy protein,vitamin and mineral and satisfies the nutrition requirement for infant growth. Development of soy infant formula could solve some problems in infant feeding,such as the deficiency of breast feeding,high price of cows' milk-based formula and infants with lactose intolerance or cows' milk protein allergy. This review gives an overview of the market of soy infant formula,its guideline,manufacturing process and safety evaluation. During the past few years,concerns have been raised over potential risks of soy infant formula,in particular with regard to its high phytoestrogen content. This review is focused on recent research progress on estimating infant exposure of isoflavones,absorption,metabolism and excretion of isoflavones,as well as the effect of isoflavones on infant growth and development.