Abstract: The extracting process of chlorogenic acid from Lonicera hypoglauca Miq. with microwave-assisted method was optimized. Oahogonal design L9( 34) method was applied to study the effect of five factors such as microwave power,ratio of material / solvent,extraction duration,time of extraction and solvent pH on the extraction efficiency based on the experimental result of single factor method. The results have shown that optimum conditions of microwave power,solvent pH,ratio of material / solvent,extraction duration and time of extraction were 400W,pH 3,1: 12,5 min and 2 times,respectively. The extraction rate of chlorogenic acid from Lonicera hypoglauca Miq was up to 4. 54% under the optimum extracting conditions. The method developed in the paper has the advantages of simple operation,higher extraction efficiency and very short extraction duration which is appropriate for the extraction of chlorogenic acid from Lonicera hypoglauca Miq.