Abstract: This paper studied ultrasonic extraction of polyphenols from Ixeris Chinensis under 50 ℃ drying. The response surface methodology was used to establish a models for Alcohol concentration( A),Processing time( B) and Material-liquid ratio( C). Results showed that alcohol concentration( P < 0. 01) and material-liquid ratio( P < 0. 05)had significant affects on extraction rate. The optimum extraction condition was: the ethanol concentration 60%,ratio of solid to liquid was 1: 20,uUltrasonic extraction for 60 minutes. Under the above conditions,the highest rate was1.84%. Under the optimum extraction conditions,the vacuum freeze drying,infrared drying,natural shade drying and natural drying were compared. The results showed that the vacuum freeze-drying has the highest yield of 3. 22%. The sun drying yield was the lowest of 1. 22%. The drying effect order were freeze drying > infrared drying > natural shade drying > sun drying. The regression equation was Y = 1. 87 + 0. 18A + 0. 056B + 0. 071C + 0. 067AB-0. 013AC + 0. 030BC- 0. 36A2- 0. 057B2- 0. 18C2.