Abstract: To evaluate the effects of Lactobacillus acidophilus La28 on relieving peripheral inflammation and improving liver function in rats induced by valproic acid, Wistar rats were intraperitoneally injected with VPA or normal saline on day 12.5 after pregnancy and the male offspring were randomly grouped as the control group, VPA group, La28 group and risperidone (MED) group (n=5). La28 group was treated with L. acidophilus La28 (109 CFU/mL) by gavage for 28 days. The control, VPA and MED groups were treated with equivalent saline and risperidone by gavage. After the intervention, peripheral inflammation, liver function and gut microbiota were evaluated. Compared with rats in VPA group, L. acidophilus La28 significantly improved peripheral inflammation and liver function in rats. The effects on IL-6, TNF-α, alanine aminotransferase (ALT) andγ-glutamyl transpeptidase (GGT) were more significant. In addition, L. acidophilus La28 might improve the peripheral inflammation and liver function through regulating the relative abundance of Allobaculumhe and Mucispirillum, increasing Firmicutes abundance, and decreasing Bacteroides abundance.
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