Abstract: In this experiment,a high-salt diet model was established in mice.The model mice were given pyroglutamic acid intervention to explore the effect of pyroglutamic acid on intestinal health and intestinal flora in mice with high-salt diet.Pathological analysis and morphological observation were performed on the small intestine of mice,followed by detection of intestinal inflammatory cytokines and albumin leakage in feces.Alpha diversity,beta diversity,and intestinal flora composition at the phylum and genus levels were analyzed by high-throughput sequencing.The results showed that pyroglutamic acid significantly alleviated the intestinal structural damage of mice caused by high-salt diet and reduced the secretion of inflammatory cytokines in small intestine.While pyroglutamic acid inhibited the significant increase in the abundance of some flora caused by high-salt diet,such as Bacteroides,Alistipes and other microorganisms.In addition,pyroglutamic acid also restored and increased the abundance of flora that had been reduced during high-salt diet,including Candidatus Arthromitus,Bifidobacterium,Lactobacillus and other probiotics.In summary,pyroglutamic acid has a significant beneficial effect on high-salt diet mice,which can stabilize the intestinal structure,reduce the level of intestinal inflammation,and improve the intestinal flora structure and abundance.
徐珒昭,汤梦琪,徐境含,等. 焦谷氨酸对高盐饮食小鼠肠道健康及肠道菌群的作用[J]. 食品与发酵工业, 2021, 47(2): 102-108.
XU Jinzhao,TANG Mengqi,XU Jinghan,et al. Effects of pyroglutamic acid on intestinal health and intestinal microflora in mice with high-salt diet[J]. Food and Fermentation Industries, 2021, 47(2): 102-108.
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