Antioxidant effect of Antarctic krill oil on aging mice
LI Hui1*, WANG Lianxin1, HAN Yunsu1, LIN Danni1, QU Lina2
1(School of Life Sciences, Liaoning University, Shenyang 110036, China) 2(Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China)
Abstract: The aim of this study was to explore the antioxidant effect of Antarctic krill oil (AKO) on aging model mice. SPF-ICR healthy male mice aged 8-10 months were randomly divided into 4 groups, low-dose group, medium-dose group, high-dose krill oil group and one negative control group. Ten mice in each group and were given a dose of 0.075 g/kg·BW, 0.150 g/kg·BW, 0.450 g/kg·BW and corn germ oil respectively. The four mice groups were dosed by gavage once a day for 30 days. After 30 days, the contents of lipid peroxide (LPO) (calculated by the content of MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and protein carbonyl (PCO) were determined. The results showed that compared with the control group, the activity of serum SOD and serum level of GSH increased considerably (P<0.05) in the medium dose of the krill oil group, and even significantly (P<0.01) in the high-dose group. The level of LPO in the medium dose group was lower (P<0.05) than the control group. However, there was no statistical difference for the level of PCO between the medium dose group and the control group (P>0.05). These results revealed AKO has an antioxidant effect on aging model mice.
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2021, Vol. 47 
