黄酮类化合物作为促进健康,预防疾病的膳食补充剂,具有抗氧化作用、抗炎、预防癌症等活性。由于它们的低毒性与高安全性,使其成为化学预防剂的最佳候选者。黄酮类化合物在对肝脏功能的影响方面,具有抗肝炎、抗肝纤维化、抗肝癌、改善肝脂质代谢、调节肝脏免疫功能等作用,其机制与抗氧化作用、抑制肿瘤坏死因子、调节细胞凋亡等相关。为了合理利用我国丰富的植物资源,更加深入研究食源性黄酮类化合物的保肝功能与作用机制以及更好地开发食源性黄酮类保健品,文中综述了近年来国内外对食源性黄酮类化合物保肝功能及其作用机制的研究进展。
Flavonoids, as some dietary supplements which can promote health,
prevent disease, have activities of antioxidant, anti-inflammatory, preventing
cancer and so on. Due to their low toxicity and high safety, it is the best
candidate for chemical prophylaxis. In the aspect of the impact on liver
function, Flavonoids have the effect of anti-hepatitis, anti-liver fibrosis, anti-liver
cancer, improve liver lipid metabolism, regulate liver immune function and so
on.The mechanisms of protective effects of flavonoids on liver are related to
anti-oxidize effect, inhibiting tumor necrosis factor, regulating cell
apoptosis and so on. In order to make reasonable use of our abundant plant
resources and to further study the mechanisms of dietary flavonoids in
protecting liver and to better develop dietary flavonoids functional foods, we
reviewed the mechanisms of protective effects of dietary flavonoids on liver in
recent years both at home and abroad.