柠檬苦素类化合物是一类含有呋喃环并且高度氧化的四环三萜类植物次生代谢产物，具有显著的抗癌、抗病毒、抗氧化、抗微生物、昆虫拒食、抗炎镇痛和防治动脉粥样硬化等多种生物活性。柠檬苦素类化合物主要存在于芸香科和楝科植物中，在柑橘籽中的含量尤为丰富。该文综述了柑橘籽中柠檬苦素类化合物的种类、结构及其生物合成途径以及近年来国内外对柠檬苦素及类似物的生物活性的研究进展，并对其在食品工业、农业、医药和畜牧业中的应用等方面进行了概述，以期为开发柑橘籽中柠檬苦素及类似物的应用提供参考。

Limonoids are a group of secondary metabolism containing furan ring and highly oxidized tetracyclic triterpene, with significant anticancer, antiviral, antioxidant, antimicrobial, insect antifeedant, antiinflammatory and analgesic atherosclerosis and other biological activities. Limonoids are mainly found in Rutaceae and Meliaceae families, and which are particularly abundant in the citrus seeds. The research on the species, structure and biosynthetic pathways of limonoids in citrus seeds and the research progress on the bioactivity of limonin and its analogues in recent years are discussed in this paper, and its application in the food industry, agriculture, medicine and animal husbandry are also reviewed, in order to provide reference for the application of limonin and its analogues in citrus seeds.