磺胺类药物是一类广谱抗菌药，价格低廉、性质稳定，广泛应用于人和动物的疾病防治。磺胺类药物的不合理使用导致其在动物性食品中有所残留，危害人体健康。建立快速、高效和简便的分析方法有利于兽药残留的有效监管。该文以基于抗原—抗体反应的免疫分析方法为主，简述了免疫半抗原的合成和新型抗体的应用，以及近几年研究较热门的分析方法，包括酶联免疫吸附测定、荧光免疫分析法、化学发光免疫分析法、胶体金免疫层析和生物传感器，以期为动物性食品安全的监控提供有益参考。

Sulfonamides are broad spectrum antimicrobial drugs, they are cheap and stable and are widely used in the prevention and treatment of diseases for humans and animals. The extensive use of sulfonamides causes their residues in edible animal food, which can endanger human health. Therefore, establishing a rapid, efficient and simple analytical methods is benefit in supervising veterinary drug residues. This review is focused on immunoassays based antigen-antibody method. A brief summary of the synthesis of hapten and application of new antibodies, as well as the popular analytical methods in recent years is presented, including enzyme-linked immunosorbent assay(ELISA), fluorescence immunoassay (FIA), chemiluminescence immunoassay (CLIA), colloid gold immunochromatography (CGIC) and biosensors. It provides a useful reference for monitoring safety of edible animal foods.