以羧甲基改性后的魔芋葡甘露聚糖为原料,牛血清蛋白为模拟药物,通过锐孔法制备出羧甲基魔芋葡甘露聚糖/海藻酸钠缓释微囊。通过体外模拟人体环境,配制人体消化液,研究了羧甲基魔芋葡甘露聚糖/海藻酸钠微囊的释药性能,同时对其释药机理进行探求。结果表明,微囊的药物在0~5 h时缓慢释放,6~9 h时持续释放,在10~12 h时释放基本趋于平缓;牛血清蛋白质量对微囊体外释放有影响,当牛血清蛋白质量为30.0 mg时,微囊的药物释放具有良好的缓释效果;微囊体外释放模型拟合表明,Higuchi方程更拟合药物体外释放行为,药物释放以Fick扩散为主。
Using carboxymethyl modified konjac glucomannan as raw material and bovine serum albumin as the mimic drug, the carboxymethyl konjac glucomannan/sodium alginate sustained microcapsules were prepared via orifice method. By simulating the human environment in vitro, the human digestive juice was formulated to study the drug release properties and mechanism of the carboxymethyl konjac glucomannan/sodium alginate microcapsules. The results showed that the microcapsules were released slowly in 0-5 h, continued to release in 6-9 h, and the release was basically gentle in 10-12 h. The quality of bovine serum albumin had an effect on the release of microcapsules. When the mass of bovine serum albumin was 30.0 mg, The drug release of microcapsules had a good sustained release effect. The model release of microcapsules showed that the Higuchi equation was more suitable for the release of the drug in vitro, and the drug release was mainly composed of Fick diffusion.
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