生产与科研应用

多孔淀粉对姜黄素的吸附

  • 俞力月 ,
  • 李海燕 ,
  • 马云翔 ,
  • 陈金凤 ,
  • 孙倩 ,
  • 苟丽娜 ,
  • 刘鑫 ,
  • 张盛贵
展开
  • (甘肃农业大学 食品科学与工程学院,甘肃 兰州,730070)
硕士研究生(张盛贵教授为通讯作者,E-mail:zhangshenggui@gsau.edu.cn)

收稿日期: 2019-09-03

  网络出版日期: 2020-04-10

基金资助

甘肃省现代化农业产业技术体系特色作物岗位专家(GARS-TSZ-4);甘肃农业大学科研启动基金(2017RCZX-46)

Study on adsorption of curcumin by porous starch

  • YU Liyue ,
  • LI Haiyan ,
  • MA Yunxiang ,
  • CHEN Jinfeng ,
  • SUN Qian ,
  • GOU Lina ,
  • LIU Xin ,
  • ZHANG Shenggui
Expand
  • (College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China)

Received date: 2019-09-03

  Online published: 2020-04-10

摘要

采用扫描电子显微镜(scanning electron microscope, SEM)、傅里叶变换红外光谱(fourier transform infrared spectroscopy, FTIR)、粒度分布、吸附能力等指标对复合物进行表征;利用差示扫描量热法(differential scanning calorimety, DSC)和水溶性分析其稳定性;通过自由基清除能力及体外模拟胃液(SGF)和肠液(SIF)环境研究其释放特性。比较SEM、FTIR结果,可以看出姜黄素被吸附在多孔中并表现为化学吸附。姜黄素以不同的质量比进行吸附,0.4wt%的负载量实现了最高的吸附能力(3.67 mg/g),吸附后样品呈淡黄色,水溶性大大提高,保留大部分抗氧化能力,体外SGF和SIF中表明具有缓释效果。该研究成功制备马铃薯多孔淀粉-姜黄素复合物,且有望扩大姜黄素在食品工业中的应用。

本文引用格式

俞力月 , 李海燕 , 马云翔 , 陈金凤 , 孙倩 , 苟丽娜 , 刘鑫 , 张盛贵 . 多孔淀粉对姜黄素的吸附[J]. 食品与发酵工业, 2020 , 46(5) : 224 -230 . DOI: 10.13995/j.cnki.11-1802/ts.022163

Abstract

For improvement of water insolubility and activity retention of curcumin, the property and release effect of potato porous starch adsorbed curcumin was investigated. The properties of complex were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), particle size distribution, and adsorption capacity analysis. The stability was analyzed via differential scanning calorimetry (DSC) and water solubility. The release characteristics were studied by free radical scavenging ability and simulated gastric juice (SGF) and intestinal fluid (SIF) environments in vitro. The results of SEM and FTIR indicated that curcumin was adsorbed in the pores, which was attributed to chemical adsorption. With various weight ratios of curcumin encapsulated in porous starch, it was found that 0.4wt% loading achieved the highest adsorption ability (3.67 mg/g). The sample (curcumin adsorbed in porous starch) was yellowish colored and well dispersed in water, whose antioxidant capacity was mostly retained. The result from SGF and SIF experiments in vitro showed a sustained release effect. Therfore, the potato porous starch curcumin complex was prepared successfully, which may work as the trigger to broaden the applications of curcumin in the food industry.

参考文献

[1] ESATBEYOGLU TUBA,HUEBBE PATRICIA,ERNST INSA M A,et al.Rimbach gerald curcumin-from molecule to biological function.[J]. Angewandte Chemie (International Edition),2012,51(22):5 308-5 332.
[2] LEONARDO ACEVEDO-GUEVARA,LEONARDO NIETO-SUAZA,LEIDY T,et al. Development of native and modified banana starch nanoparticles as vehicles for curcumin[J]. International Journal of Biological Macromolecules,2018,111:498-504.
[3] KUNNUMAKKARA A B, ANAND P, AGGARWAL B B. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of difierent cancers through interaction with multiple cell signaling proteins[J]. Cancer Letters, 2008,269(2):199-225.
[4] ANAND P, KUNNUMAKKARA A B, NEWMAN R A, et al. Bioavailability of curcumin: problems and promises[J]. Mol Ecular Pharmaceutics, 2007,4(6):807-818.
[5] HEGER M, VAN GOLEN R F, BROEKGAARDEN M, et al. The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancers[J]. Pharmacological Reviews, 2014,66(1): 222-307.
[6] ANAND P, KUNNUMAKKARA A B, NEWMAN R A. Bioavailability of curcumin: problems and promises [J]. Molecular Pharmaceutics, 2007,4(6): 807-818.
[7] 李帅,宋少婷,张振显,等.姜黄素缓释载体研究进展[J].上海中医药杂志,2018,52(7):102-104.
[8] 高振珅,王兰. 姜黄素羟丙基-β-环糊精包合物的制备及其性质研究[J].中草药,2012(10):1 951-1 956.
[9] 朱雯洁,黄莉君,叶曾联,等.姜黄素微球制备工艺研究[J].广州化工,2017(23):66-68.
[10] GAO Y, LI Z G,SUN M, et al. Preparation, characterization, pharmacokinetics, and tissue distribution of curcumin nanosuspension with TPGS as stabilizer[J]. Drug Development and Industrial Pharmacy, 2010,36(10):1 225-1 234.
[11] LI J, LEE I W, SHIN G H, et al. Curcumin-Eudragit® E PO solid dispersion: A simple and potent method to solve the problems of curcumin[J]. European Journal of Pharmaceutics and Biopharmaceutics,2015,94:322-332.
[12] ZHANG B, CUI D, LIU M, et al. Corn porous starch: Preparation, characterization and adsorption property[J]. International Journal of Biological Macromolecules, 2012, 50: 250-256.
[13] MEER TARIQUE ALI,RITESH FULE,AJAY SAV,et al. Porous starch: a novel carrier for solubility enhancement of carbamazepine[J]. AAps PharmSciTech,2013,14(3):919-926.
[14] BELINGHERI C, GIUSSANI B, RODRIGUEZ-ESTRADA M T, et al. Oxidative stability of high-oleic sunflower oil in a porous starch carrier[J]. Food Chemistry, 2015, 166: 346-351.
[15] LUO Z, CHENG W, CHEN H, et al. Preparation and properties of enzyme-modified cassava starch-zinc complexes[J]. Journal of Agricultural and Food Chemistry, 2013, 61(19): 4 631-4 638.
[16] MAJZOOBI M, HEDAYATI S, FARAHNAKY A. Functional properties of microporous wheat starch produced by α-amylase and sonication[J]. Food Bioscience, 2015, 11: 79-84.
[17] BELINGHERI CLAUDIA,CURTI ELENA,FERRILLO ANTONIO,et al. Evaluation of porous starch as a flavour carrier[J]. Food & Function,2011,3(3):255-261.
[18] WANG Yufeng,YE Hong,ZHOU Chunhong,et al. Study on the spray-drying encapsulation of lutein in the porous starch and gelatin mixture[J]. European Food Research and Technology,2012,234(1):157-163.
[19] CAI Y. Porous microsphere and its applications[J]. International Journal of Nanomedicine,2013, 8:1 111-1 120.
[20] CHANG P R, YU J G, MA X F. Preparation of porous starch and its use as a structure-directing agent for production of porous zinc oxide[J]. Carbohydrate Polymers, 2011,83: 1 016-1 019.
[21] LI Jinglei,GYE HWA SHIN,IL WOO LEE,et al. Soluble starch formulated nanocomposite increases water solubility and stability of curcumin[J]. Food Hydrocolloids,2016,56:41-49.
[22] 高凤苑,关欣,韩良亮,等.木薯淀粉水凝胶负载姜黄素及缓释性能研究[J].食品与发酵工业,2019,45(11):204-210.
[23] KIM J K, SRINIVASAN P, KIM J H, et al. Structural andantioxidant properties of gamma irradiated hyaluronic acid[J]. Food Chemistry, 2008,109(4): 763-770.
[24] EFSTATHIA I PARAMERA, SPYROS J K. Yeast cells and yeast-based materials for microenca psulation [J].Microencapsulation in the Food Industry,2014,4(23):267-281.
[25] PEREIRA A G B, FAJARDO A R, NOCCHI S, et al.Starch-based microspheres for sustained-release of curcumin: Preparation and cytotoxic effect on tumor cells[J]. Carbohydrate Polymers, 2013,98(1): 711-720.
[26] 张攀峰. 不同品种马铃薯淀粉结构与性质的研究[D].广州:华南理工大学,2012
[27] PETER R CHANG,YU Jiugao,MA Xiaofei. Preparation of porous starch and its use as a structure-directing agent for production of porous zinc oxide[J]. Carbohydrate Polymers,2010,83(2):1 016-1 019.
[28] MOHAN P R K, SREELAKSHMI G, MURALEEDHARAN C V, et al. Water soluble complexes of curcumin with cyclodextrins: Characterization by FT-Raman spectroscopy[J]. Vibrational Spectroscopy, 2012,62: 77-84.
[29] OLGA G, STYLIANI C, IOANNIS R G. Coencapsulation of Ferulic and Gallic acid in hp-b-cyclodextrin[J]. Food Chemistry, 2015,185: 33-40.
[30] 宋菲,王挥,陈卫军,等.差示扫描量热法(DSC)在油脂分析中的应用[J]. 热带农业科学,2014(6):85-88;93.
[31] NEO Y P, RAY S, JIN J, et al. Encapsulation of food grade antioxidant in natural biopolymer by electrospinning technique:A physicochemical study based on zein-gallic acid system[J]. Food Chemistry, 2013,136(2): 1 013-1 021.
[32] TONON R V, PEDRO R B, GROSSO C R, et al. Microencapsulation of flaxseed oil by spray drying: Effect of oil load and type of wall material[J]. Drying Technology, 2012,30: 1 491-1 501.
[33] QIAN Dayan,PETER R, MA Xiaofei. Preparation of controllable porous starch with different starch concentrations by the single or dual freezing process[J]. Carbohydrate Polymers,2011,86(3):1 181-1 186.
[34] O′TOOLE M G, HENDERSON R M, SOUCY P A, et al. Curcumin encapsulation in submicrometer spray-dried chitosan/Tween 20 particles[J]. Biomacromolecules, 2012,13(8): 2 309-2 314.
[35] JIN S P, LIU M Z, ZHANG F, et al. Synthesis and characterization of pH-sensitivity semi-IPN hydrogel based on hydrogen bond between poly(N-vinylpyrrolidone) and poly(acrylic acid)[J]. Polymer, 2006,47(5): 1 526-1 532.
文章导航

/