食品与发酵工业 >

2020 , Vol. 46 >Issue 6: 292 - 300

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.022778

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枸杞多糖的提取方式、结构及生物活性研究进展

  • 叶兴乾 ,
  • 周声怡 ,
  • 姚舒婷 ,
  • 吴文艳 ,
  • 陈士国
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  • (浙江大学 生物系统工程与食品科学学院, 馥莉食品研究院浙江省农产品加工技术研究重点实验室, 浙江 杭州, 310058)
叶兴乾(教授)和周声怡(硕士研究生)为共同第一作者(叶兴乾教授为通讯作者,E-mail: psu@zju.edu.cn)

收稿日期: 2019-11-11

  网络出版日期: 2020-04-24

基金资助

国家重点研发计划(2016YFD0400405);国家重点研发计划政府间国际科技创新合作专项(2017YFE0122300);国家基金面上项目(31871815)

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Research progress on extraction methods, structures and bioactivities of Goji (Lycium barbarum) polysaccharides

  • YE Xingqian ,
  • ZHOU Shengyi ,
  • YAO Shuting ,
  • WU Wenyan ,
  • CHEN Shiguo
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  • (College of Biosystems Engineering and Food Science, Zhejiang University, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Hangzhou 310058,China)

Received date: 2019-11-11

  Online published: 2020-04-24

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摘要

枸杞(Lycium barbarum)果实为传统的名贵滋补药材,在我国有2 000多年的历史。枸杞多糖(Lycium barbarum polysacchavides,LBP)是枸杞中最重要的活性成分之一。在过去的几年中,LBP由于具有良好的生物活性而备受关注。然而,多糖的生物活性与其化学结构密切相关,而化学结构又被提取方式所影响。该文对LBP的提取方法、化学结构和主要生物活性的对应关系进行总结,比较通过不同提取方式制备得到的枸杞多糖的不同之处,旨在提出枸杞多糖的构效关系,关注特定结构和活性的枸杞多糖的定向提取。大部分研究表明,采用热水提取法制备的枸杞多糖多为含有酸性糖组分的杂多糖,其中的中性糖组分多以阿拉伯糖、葡萄糖及半乳糖为主。此外,枸杞多糖通过不同的机制显示出良好的抗氧化、免疫调节、抗肿瘤及神经保护活性。

关键词： 枸杞多糖; 提取方式; 化学结构; 生物活性; 构效关系

本文引用格式

叶兴乾 , 周声怡 , 姚舒婷 , 吴文艳 , 陈士国 . 枸杞多糖的提取方式、结构及生物活性研究进展[J]. 食品与发酵工业, 2020 , 46(6) : 292 -300 . DOI: 10.13995/j.cnki.11-1802/ts.022778

Abstract

Goji (Lycium barbarum) berries have been used as a traditional medicinal herb and food supplement in China for more than 2 000 years. Goji (Lycium barbarum) polysaccharides (LBP) are one of the most important active components in Goji berries. In the past few years, LBP have attracted great attention due to their great bioactivities. However, the bioactivities of polysaccharides are closely related to their chemical structures, while the chemical structures are affected by the extraction methods. Hence, the present paper summarized the correspondence relationship among extraction methods, chemical structures and major bioactivities of LBP, and compared the differences between the polysaccharides obtained by different extraction methods. This study aims to propose the structure-function relationship and to focus on the targeted extractions of LBP with specific structures and bioactivities. Most of the LBP prepared by hot water extraction are heteropolysaccharides containing acidic glycoconjugate and the neutral sugar components are mostly arabinose, glucose and galactose. Moreover, LBP possess good antioxidant, immunomodulatory, antitumor and neuroprotective activities via different mechanisms.

Key words： Goji polysaccharide; extraction methods; chemical structures; bioactivities; structure-function relationship

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