该文探讨一种含L-精氨酸和抗氧化物质(山楂提取物、知母提取物和虾青素)组方对小鼠免疫功能的影响。将SPF级雄性ICR小鼠随机分为四组,分别为对照组和受试物低、中和高剂量组(0.133、0.267和0.800 g/kg·BW)。连续灌胃30 d后,测定小鼠主要免疫器官脏器系数、细胞免疫功能指标、体液免疫功能指标、非特异性免疫功能指标。结果显示,该组方(中、高剂量)能显著提高淋巴细胞增殖能力和NK细胞活性,低、中、高剂量均能显著提高小鼠巨噬细胞吞噬鸡红细胞百分率及吞噬指数。在该实验条件下,组方具有增强小鼠免疫的功能。
In this paper, the effects of a formula composed of L-argarginine, crataegus extract, chinonin extract and astaxanthin on the immune function were studied using mouse model. SPF male ICR mice were randomly divided into four groups:a control group and low, medium and high dose groups. After 30 days of continuous intragastric administration, mice’s organ coefficients, cellular immune function indexes, humoral immune function indexes and non-specific immune function indexes were measured. The results showed that medium and high doses groups of the formula could significantly increase the lymphocyte proliferation ability and NK cell activity and low, medium and high doses groups could significantly increase the percentages of phagocytic chicken erythrocytes and phagocytic index of mouse macrophages. Under the experimental conditions, this formula has the function of enhancing the immunity of mice.
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