食品与发酵工业 >

2020 , Vol. 46 >Issue 18: 245 - 251

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.023889

综述与专题评论

微生物发酵转化甘露醇的研究进展

  • 胡梦莹 ,
  • 张涛
展开
  • 1(江南大学,食品科学与技术国家重点实验室,江苏 无锡,214122)
    2(江南大学 食品学院,江苏 无锡,214122)
硕士研究生(张涛教授为通讯作者,E-mail:zhangtao@jiangnan.edu.cn)

收稿日期: 2020-03-08

  修回日期: 2020-04-25

  网络出版日期: 2020-10-23

基金资助

国家食品科学与工程一流学科建设项目(JUFSTR20180203)

收起

Research progress on mannitol production by microbial fermentation

  • HU Mengying ,
  • ZHANG Tao
Expand
  • 1(State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China)
    2(School of Food Science and Technology, Jiangnan University, Wuxi 214122, China)

Received date: 2020-03-08

  Revised date: 2020-04-25

  Online published: 2020-10-23

Fold

摘要

甘露醇是一种多元醇,存在于许多植物和微生物中,因其具有众多独特的性质,广泛应用于食品、医药和化工等行业,具有较大的经济价值。目前甘露醇的生产方法主要有4种:植物提取法、化学合成法、酶转化法和微生物发酵法,其中工业生产主要选用的是化学合成法。该文通过对这4种方法进行介绍与利弊比较,发现微生物发酵法有许多优点,例如不易产生副产物山梨醇、条件温和能耗低、不需要高度纯化的底物、不受原料和季节的限制、适宜大规模生产等,具有很大的取代化学合成法应用于工业生产的潜力,因此提出一些切实可行的方法建议,给甘露醇的后期发展以参考。

关键词： 甘露醇生产; 发酵; 微生物; 培养基; 菌株选育

本文引用格式

胡梦莹 , 张涛 . 微生物发酵转化甘露醇的研究进展[J]. 食品与发酵工业, 2020 , 46(18) : 245 -251 . DOI: 10.13995/j.cnki.11-1802/ts.023889

Abstract

Mannitol is a kind of sugar alcohol and naturally exists in fungi, bacteria, yeasts and many plants. Benefit from its desirable properties, mannitol is widely used in food industry, medicine and pharmaceutical products. It can be produced by plant extraction, chemical synthesis, enzyme transformation and microbial fermentation. At present, chemical synthesis is the main method for industrial production. However, compared with the other three methods, microbial fermentation is a better way for mannitol producing due to some advantages such as low co-product sorbitol production, mild reaction conditions, low energy consumption, not limited to high substrate purity, easy to be commercialized in large-scale, not limited to sources and seasons, etc. It has great potential to replace chemical synthesis in mannitol industrial production. This review summarized the most recent research advances on microbial fermentation, including the developments of fungi-, bacterial- and yeast-based transformations, and some practical development suggestions. This review might give some references for future development of mannitol.

Key words： mannitol production; fermentation; microorganism; medium; strain breeding

参考文献

[1] SAHA B C, RACINE F M. Biotechnological production of mannitol and its applications[J]. Applied Microbiology and Biotechnology, 2011, 89(4): 879-891.
[2] STOOP J M H, WILLIAMSON J D, CONKLING M A, et al. Characterization of nad-dependent mannitol dehydrogenase from celery as affected by ions, chelators, reducing agents and metabolites[J]. Plant Science, 1998, 131(1): 43-51.
[3] YUN J W, KIM D H. A comparative study of mannitol production by two lactic acid bacteria[J]. Journal of Fermentation and Bioengineering, 1998, 85(2): 203-208.
[4] SOETAERT W. Production of D-mannitol and D-lactic acid by fermentation with leuconostoc mesenteroides[J]. Agro Food Industry Hi-Tech,1995, 6: 41-44.
[5] GROLEAU D, CHEVALIER P, YUEN T. Production of polyols and ethanol by the osmophilic yeast zygosaccharomyces-rouxii[J]. Biotechnology Letters, 1995, 17(3): 315-320.
[6] WISSELINK H, WEUSTHUIS R, EGGINK G, et al. Mannitol production by lactic acid bacteria: A review[J]. International Dairy Journal, 2002, 12(2-3): 151-161.
[7] SCHIWECK H, BÄR A, VOGEL R, et al. Sugar Alcohols in Ullmann’s Encyclopedia of Industrial Chemistry[M]. Weinheim:Verlag Chemie, 1994: 413.
[8] WEYMARN F N W, KIVIHARJU K J, JÄÄSKELÄINEN S T, et al. Scale-up of a new bacterial mannitol production process[J]. Biotechnology Progress, 2003, 19(3): 815-821.
[9] DAI Y, MENG Q, MU W, et al. Recent advances in the applications and biotechnological production of mannitol[J]. Journal of Functional Foods, 2017, 36: 404-409.
[10] GHOREISHI S M, SHAHRESTANI R G. Innovative strategies for engineering mannitol production[J]. Trends in Food Science & Technology, 2009, 20(6-7): 263-270.
[11] GREMBECKA M. Sugar alcohols-their role in the modern world of sweeteners: A review[J]. European Food Research and Technology, 2015, 241(1): 1-14.
[12] OHREM H L, SCHORNICK E, KALIVODA A, et al. Why is mannitol becoming more and more popular as a pharmaceutical excipient in solid dosage forms?[J].Pharmaceutical Development and Technology, 2014, 19(3): 257-262.
[13] LI X, GILMOUR P S, DONALDSON K, et al. Free radical activity and pro-inflammatory effects of particulate air pollution (pm10) in vivo and in vitro[J]. Thorax, 1996, 51(12): 1 216-1 222.
[14] ANDRÉ P, VILLAIN F. Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: A literature review[J]. International Journal of Cosmetic Science, 2017, 39(4): 355-360.
[15] RICHTER D F E, KIRST G. D-mannitol dehydrogenase and d-mannitol-1-phosphate dehydrogenase in platymonas subcordiformis: Some characteristics and their role in osmotic adaptation[J]. Planta, 1987, 170(4): 528-534.
[16] VRANCKEN G, RIMAUX T, DE VUYST L, et al. Low-Calorie Sugars Produced by Lactic Acid Bacteria[M]. Biotechnology of Lactic Acid Bacteria: Novel Applications, 2010: 193-209.
[17] KIRK R E, OTHMER D F, MANN C A. Encyclopedia of chemical technology[J]. The Journal of Physical Chemistry, 1949, 53(4): 591.
[18] GHOREISHI S M, SHARIFI S. Modeling of supercritical extraction of mannitol from plane tree leaf [J]. Journal of Pharmaceutical and Biomedical Analysis, 2001, 24(5-6): 1 037-1 048.
[19] 陈莉, 王洁, 陈继承, 等. 响应面优化超声辅助酸解醇提海带甘露醇工艺研究[J]. 食品工业, 2017, 38(3): 1-4.
[20] RACINE F M, SAHA B C. Production of mannitol by Lactobacillus intermedius NRRL B-3693 in fed-batch and continuous cell-recycle fermentations[J]. Process Biochemistry, 2007, 42(12): 1 609-1 613.
[21] SAVERGAVE L S, GADRE R V, VAIDYA B K, et al. Two-stage fermentation process for enhanced mannitol production using Candida magnoliae mutant R9[J]. Bioprocess and Biosystems Engineering, 2013, 36(2): 193-203.
[22] BHATT S M, MOHAN A, SRIVASTAVA S K. Challenges in enzymatic route of mannitol production[J]. ISRN Biotechnol, 2013:914 187.
[23] NISHISE H, NAGAO A, TANI Y, et al. Further characterization of glycerol dehydrogenase from Cellulomonas sp. NT3060[J]. Agricultural and Biological Chemistry, 1984, 48(6): 1 603-1 609.
[24] HOWALDT M, GOTTLOB A, KULBE K D, et al. Simultaneous conversion of glucose/fructose mixtures in a membrane reactor[J]. Annals of the New York Academy of Sciences, 1988, 542: 400-405.
[25] PARMENTIER S, ARNAUT F, SOETAERT W, et al. Enzymatic production of D-mannitol with the Leuconostoc pseudomesenteroides mannitol dehydrogenase coupled to a coenzyme regeneration system[J]. Biocatalysis and Biotransformation, 2005, 23(1): 1-7.
[26] CHENAULT H K, WHITESIDES G M. Regeneration of nicotinamide cofactors for use in organic synthesis[J]. Applied Biochemistry and Biotechnology, 1987, 14(2): 147-197.
[27] JENNINGS D H. Polyol metabolism in fungi[J]. Advances in Microbial Physiology, 1985, 25: 149-193.
[28] VON WEYMARN N. Process development for mannitol production by lactid acid bacteria[D]. Helsinki: Helsinki University of Technology, 2002.
[29] PAREKH S, VINCI V A, STROBEL R J. Improvement of microbial strains and fermentation processes[J]. Applied Microbiology and Biotechnology, 2000, 54(3): 287-301.
[30] DUAN R, LI H, LI H, et al. Enhancing the production of D-mannitol by an artificial mutant of Penicillium sp. T2-M10[J]. Applied Biochemistry and Biotechnology, 2018, 186(4): 990-998.
[31] 郑琳, 金铁, 崔福顺, 等. 乳酸菌生产甘露醇的研究进展[J]. 食品工业, 2017, 38(1): 226-229.
[32] SAHA B C. Production of mannitol from inulin by simultaneous enzymatic saccharification and fermentation with Lactobacillus intermedius NRRL B-3693[J]. Enzyme and Microbial Technology, 2006, 39(5): 991-995.
[33] LEE J K, SONG J Y, KIM S Y. Controlling substrate concentration in fed-batch Candida magnoliae culture increases mannitol production[J]. Biotechnology Progress, 2003, 19(3): 768-775.
[34] NEVES A R, RAMOS A, SHEARMAN C, et al. Metabolic characterization of Lactococcus lactis deficient in lactate dehydrogenase using in vivo 13C-NMR[J]. European Journal of Biochemistry, 2000, 267(12): 3 859-3 868.
[35] PARK Y C, OH E J, JO J H, et al. Recent advances in biological production of sugar alcohols[J]. Current Opinion in Biotechnology, 2016, 37: 105-113.
[36] BAEK H, SONG K H, PARK S M, et al. Role of glucose in the bioconversion of fructose into mannitol by Candida magnoliae[J]. Biotechnology Letters, 2003, 25(10): 761-765.
[37] AXELSSON L. Lactic acid bacteria: Classification and physiology[J]. Food Science and Technology New York Marcel Dekker, 2004, 139: 1-66.
[38] OTGONBAYAR G E, EMO H J, KIM B S, et al. Mannitol production by Leuconostoc citreum KACC 91348P isolated from Kimch[J]. Journal of Mocrobiology and Biotechnology, 2011, 21(9): 968-971.
[39] 王海燕. 霍乱弧菌两类菌株甘露醇PTS基因簇功能研究及甘露醇发酵快慢机制探讨[D]. 苏州:苏州大学, 2007.
[40] SONG K H, LEE J K, SONG J Y, et al. Production of mannitol by a novel strain of Candida magnoliae[J]. Biotechnology Letters, 2002, 24(1): 9-12.
[41] MENG Q, ZHANG T, WEI W, et al. Production of mannitol from a high concentration of glucose by Candida parapsilosis SK26.001[J]. Applied Biochemistry and Biotechnology, 2017, 181(1): 391-406.
[42] WANG P M, ZHENG D Q, LIU T Z, et al. The combination of glycerol metabolic engineering and drug resistance marker-aided genome shuffling to improve very-high-gravity fermentation performances of industrial Saccharomyces cerevisiae[J]. Bioresource Technology, 2012, 108: 203-210.
[43] HELANTO M, AARNIKUNNAS J, VON WEYMARN N, et al. Improved mannitol production by a random mutant of Leuconostoc pseudomesenteroides[J]. Journal of Biotechnology, 2005, 116(3): 283-294.
[44] 赵雅童, 何光明, 瓮茹茹, 等. 甘露醇磷酸化酶基因的敲除对d-甘露醇合成的影响[J]. 生物技术通报, 2019, 35(5): 118-124.
[45] COSTENOBLE R, ADLER L, NIKLASSON C, et al. Engineering of the metabolism of Saccharomyces cerevisiae for anaerobic production of mannitol[J]. FEMS Yeast Research, 2003, 3(1): 17-25.
[46] PAPAGIANNI M, LEGISˇA M. Increased mannitol production in Lactobacillus reuteri ATCC 55730 production strain with a modified 6-phosphofructo-1-kinase[J]. Journal of Biotechnology, 2014, 181: 20-26.
[47] YU C, CAO Y J, ZOU H B, et al. Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols[J]. Applied Microbiology and Biotechnology, 2011, 89(3): 573-583.
[48] HEUSER F, MARIN K, KAUP B, et al. Improving d-mannitol productivity of Escherichia coli: Impact of NAD, CO2 and expression of a putative sugar permease from Leuconostoc pseudomesenteroides[J]. Metabolic Engineering, 2009, 11(3): 178-183.
[49] ZHANG M, GU L, CHENG C, et al. Recent advances in microbial production of mannitol: Utilization of low-cost substrates, strain development and regulation strategies[J]. World Journal of Microbiology and Biotechnology, 2018, 34(3): 41.
[50] SAHA B C, NAKAMURA L K. Production of mannitol and lactic acid by fermentation with Lactobacillus intermedius NRRL B-3693[J]. Biotechnology and Bioengineering, 2003, 82(7): 864-871.
[51] 罗希, 曹海龙, 张卉妍, 等. 以菊粉为底物全细胞催化生产甘露醇[J]. 大连工业大学学报, 2017, 36(4): 235-239.
[52] LEE J K, OH D K, SONG H Y, et al. Ca2+ and Cu2+ supplementation increases mannitol production by Candida magnoliae[J]. Biotechnology Letters, 2007, 29(2): 291-294.
[53] SAHA B C. Effect of salt nutrients on mannitol production by Lactobacillus intermedius NRRL B-3693[J]. Journal of Industrial Microbiology and Biotechnology, 2006, 33(10): 887-890.
Options
文章导航

/

〈 〉

技术支持：北京玛格泰克科技发展有限公司