采用4种真菌代谢产物分别添加的方式对纳塔尔链霉菌菌株进行诱导,考察对菌株合成纳他霉素的促进作用。结果表明,不同来源的代谢产物以及代谢产物制备方式的差异对菌株的纳他霉素产量影响不同,其中黑曲霉和产黄青霉代谢产物中的诱导子成分具有较明显正向调节作用,当真菌诱导子在纳他霉素发酵12h以5%的添加量加入时,发酵产物纳他霉素产量达到对照的209.1%、262.8%。

To investigate the effect of fungal metabolites on improvement of natamycin,four kinds of fungal metabolites were used to induce Streptomyces natalensis.The results showed that metabolites derived from different fungi and different preparation methods had different impacts on yield of natamycin.The up-regulation of elicitors prepared from Aspergillus niger and Penicillium chrysogenum was effective.When 5% elicitors were added into the medium in which Streptomyces natalensis was grown for 12h,the yield of natamycin in culture broth reached 209.1% and 262.8% comparing with the control.