细胞高密度培养是指在人工条件下模拟体内生长环境,使细胞在生物反应器中高密度生长,从而获得大量的细胞及其代谢产物。该技术可以减少设备投入,缩短生产周期,降低生产成本,提高产物的比生产率,可极大地满足市场的需求。文中就国内外对该技术的应用研究及其主要的培养方式的研究状况进行了综述。

High cell density culture refers to the simulation of artificial environment of human body in bioreactor for high-density cell growth and the yield of great amount of cells and their metabolites.This technique can reduce the cost of the equipment,production,shorten the production cycle,and dramatically improve productivity to meet the market demand.This paper reviews the application research of this technique and the research condition of the key culture methods.