研究了一种白皮杉醇的简便合成方法,以3,4-二甲氧基苄醇为原料,经溴代、Arbuzov重排、Wittig-Horn-er反应和脱甲基4步反应得到白皮杉醇,并对目标产物的结构采用IR,1H NMR及13 C NMR进行了表征。讨论了白皮杉醇的抗氧化活性,包括还原力、清除DPPH自由基和羟基自由基的能力,并与白藜芦醇、TBHQ、BHT和儿茶素作对比。结果表明:白皮杉醇具有较强的抗氧化性能,还原能力和清除羟基自由基的能力均高于白藜芦醇、TBHQ、BHT和儿茶素;其半抑制率IC50分别为DPPH自由基16.57μg/mL、羟基自由基270.00μg/mL。

A convenient method for the practical synthesis of piceatannol is described.Starting from the readily available 3,4-dimethoxybenzyl alcohol,through bromation、Arbuzov rearrangement、Wittig-Horner reaction and demethylation,we obtained the piceatannol.The product was confirmed by IR,1H NMR and 13C NMR.The antioxidant activity of piceatannol was evaluated with different antioxidant tests,including reducing power,free radical scavenging and hydroxyl radical scavenging respectively in vitro.The antioxidant activities were compared with resveratrol、TBHQ、BHT and catechin.The results showed that piceatannol had strong antioxidant activity.The reducing power and free radical scavenging ability were both higher than resveratrol、TBHQ、BHT and catechin.IC50 of piceatannol on scavenging free radical and hydroxyl radical were 16.57 μg/mL and 270.00 μg/mL.